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A previously unrecognized superfamily of macro-conotoxins includes an inhibitor of the sensory neuron calcium channel Cav2.3.
Hackney CM, Flórez Salcedo P, Mueller E, Koch TL, Kjelgaard LD, Watkins M, Zachariassen LG, Tuelung PS, McArthur JR, Adams DJ, Kristensen AS, Olivera B, Finol-Urdaneta RK, Safavi-Hemami H, Morth JP, Ellgaard L. Hackney CM, et al. PLoS Biol. 2023 Aug 3;21(8):e3002217. doi: 10.1371/journal.pbio.3002217. eCollection 2023 Aug. PLoS Biol. 2023. PMID: 37535677 Free PMC article.
Using Constellation Pharmacology to Characterize a Novel α-Conotoxin from Conus ateralbus.
Neves JLB, Urcino C, Chase K, Dowell C, Hone AJ, Morgenstern D, Chua VM, Ramiro IBL, Imperial JS, Leavitt LS, Phan J, Fisher FA, Watkins M, Raghuraman S, Tun JO, Ueberheide BM, McIntosh JM, Vasconcelos V, Olivera BM, Gajewiak J. Neves JLB, et al. Mar Drugs. 2024 Feb 29;22(3):118. doi: 10.3390/md22030118. Mar Drugs. 2024. PMID: 38535458 Free PMC article.