R01 NS100023/NS/NINDS NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2016	1
2017	1
2018	4
2019	4
2020	2
2021	1
2023	2
2024	0

1

X-Linked Spinal and Bulbar Muscular Atrophy: From Clinical Genetic Features and Molecular Pathology to Mechanisms Underlying Disease Toxicity.

Cortes CJ, La Spada AR. Cortes CJ, et al. Adv Exp Med Biol. 2018;1049:103-133. doi: 10.1007/978-3-319-71779-1_5. Adv Exp Med Biol. 2018. PMID: 29427100 Review.

2

TFEB dysregulation as a driver of autophagy dysfunction in neurodegenerative disease: Molecular mechanisms, cellular processes, and emerging therapeutic opportunities.

Cortes CJ, La Spada AR. Cortes CJ, et al. Neurobiol Dis. 2019 Feb;122:83-93. doi: 10.1016/j.nbd.2018.05.012. Epub 2018 May 28. Neurobiol Dis. 2019. PMID: 29852219 Free PMC article. Review.

3

X-linked SBMA model mice display relevant non-neurological phenotypes and their expression of mutant androgen receptor protein in motor neurons is not required for neuromuscular disease.

Gromova A, Cha B, Robinson EM, Strickland LM, Nguyen N, ElMallah MK, Cortes CJ, La Spada AR. Gromova A, et al. Acta Neuropathol Commun. 2023 Jun 2;11(1):90. doi: 10.1186/s40478-023-01582-1. Acta Neuropathol Commun. 2023. PMID: 37269008 Free PMC article.

4

Antagonistic effect of cyclin-dependent kinases and a calcium-dependent phosphatase on polyglutamine-expanded androgen receptor toxic gain of function.

Piol D, Tosatto L, Zuccaro E, Anderson EN, Falconieri A, Polanco MJ, Marchioretti C, Lia F, White J, Bregolin E, Minervini G, Parodi S, Salvatella X, Arrigoni G, Ballabio A, La Spada AR, Tosatto SCE, Sambataro F, Medina DL, Pandey UB, Basso M, Pennuto M. Piol D, et al. Sci Adv. 2023 Jan 6;9(1):eade1694. doi: 10.1126/sciadv.ade1694. Epub 2023 Jan 6. Sci Adv. 2023. PMID: 36608116 Free PMC article.

5

Deterioration of muscle force and contractile characteristics are early pathological events in spinal and bulbar muscular atrophy mice.

Gray AL, Annan L, Dick JRT, La Spada AR, Hanna MG, Greensmith L, Malik B. Gray AL, et al. Dis Model Mech. 2020 May 26;13(5):dmm042424. doi: 10.1242/dmm.042424. Dis Model Mech. 2020. PMID: 32152060 Free PMC article.

6

Low-Cost Gait Analysis for Behavioral Phenotyping of Mouse Models of Neuromuscular Disease.

Wertman V, Gromova A, La Spada AR, Cortes CJ. Wertman V, et al. J Vis Exp. 2019 Jul 18;(149):10.3791/59878. doi: 10.3791/59878. J Vis Exp. 2019. PMID: 31380846 Free PMC article.

7

Gene therapy with AR isoform 2 rescues spinal and bulbar muscular atrophy phenotype by modulating AR transcriptional activity.

Lim WF, Forouhan M, Roberts TC, Dabney J, Ellerington R, Speciale AA, Manzano R, Lieto M, Sangha G, Banerjee S, Conceição M, Cravo L, Biscans A, Roux L, Pourshafie N, Grunseich C, Duguez S, Khvorova A, Pennuto M, Cortes CJ, La Spada AR, Fischbeck KH, Wood MJA, Rinaldi C. Lim WF, et al. Sci Adv. 2021 Aug 20;7(34):eabi6896. doi: 10.1126/sciadv.abi6896. Print 2021 Aug. Sci Adv. 2021. PMID: 34417184 Free PMC article.

8

Selective modulation of the androgen receptor AF2 domain rescues degeneration in spinal bulbar muscular atrophy.

Badders NM, Korff A, Miranda HC, Vuppala PK, Smith RB, Winborn BJ, Quemin ER, Sopher BL, Dearman J, Messing J, Kim NC, Moore J, Freibaum BD, Kanagaraj AP, Fan B, Tillman H, Chen PC, Wang Y, Freeman BB III, Li Y, Kim HJ, La Spada AR, Taylor JP. Badders NM, et al. Nat Med. 2018 May;24(4):427-437. doi: 10.1038/nm.4500. Epub 2018 Mar 5. Nat Med. 2018. PMID: 29505030 Free PMC article.

9

Transcriptional regulation of core autophagy and lysosomal genes by the androgen receptor promotes prostate cancer progression.

Blessing AM, Rajapakshe K, Reddy Bollu L, Shi Y, White MA, Pham AH, Lin C, Jonsson P, Cortes CJ, Cheung E, La Spada AR, Bast RC Jr, Merchant FA, Coarfa C, Frigo DE. Blessing AM, et al. Autophagy. 2017 Mar 4;13(3):506-521. doi: 10.1080/15548627.2016.1268300. Epub 2016 Dec 15. Autophagy. 2017. PMID: 27977328 Free PMC article.

10

Tight expression regulation of senataxin, linked to motor neuron disease and ataxia, is required to avert cell-cycle block and nucleolus disassembly.

Bennett CL, Sopher BL, La Spada AR. Bennett CL, et al. Heliyon. 2020 Jun 13;6(6):e04165. doi: 10.1016/j.heliyon.2020.e04165. eCollection 2020 Jun. Heliyon. 2020. PMID: 32577562 Free PMC article.

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