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Year | Number of Results |
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2020 | 1 |
2021 | 1 |
2022 | 2 |
2023 | 1 |
2024 | 1 |
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6 results
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m1A in CAG repeat RNA binds to TDP-43 and induces neurodegeneration.
Nature. 2023 Nov;623(7987):580-587. doi: 10.1038/s41586-023-06701-5. Epub 2023 Nov 8.
Nature. 2023.
PMID: 37938769
Free PMC article.
Uninterrupted CAG repeat drives striatum-selective transcriptionopathy and nuclear pathogenesis in human Huntingtin BAC mice.
Gu X, Richman J, Langfelder P, Wang N, Zhang S, Bañez-Coronel M, Wang HB, Yang L, Ramanathan L, Deng L, Park CS, Choi CR, Cantle JP, Gao F, Gray M, Coppola G, Bates GP, Ranum LPW, Horvath S, Colwell CS, Yang XW.
Gu X, et al.
Neuron. 2022 Apr 6;110(7):1173-1192.e7. doi: 10.1016/j.neuron.2022.01.006. Epub 2022 Feb 2.
Neuron. 2022.
PMID: 35114102
Free PMC article.
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Mapping brain gene coexpression in daytime transcriptomes unveils diurnal molecular networks and deciphers perturbation gene signatures.
Wang N, Langfelder P, Stricos M, Ramanathan L, Richman JB, Vaca R, Plascencia M, Gu X, Zhang S, Tamai TK, Zhang L, Gao F, Ouk K, Lu X, Ivanov LV, Vogt TF, Lu QR, Morton AJ, Colwell CS, Aaronson JS, Rosinski J, Horvath S, Yang XW.
Wang N, et al.
Neuron. 2022 Oct 19;110(20):3318-3338.e9. doi: 10.1016/j.neuron.2022.09.028.
Neuron. 2022.
PMID: 36265442
Free PMC article.
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Mutant huntingtin protein induces MLH1 degradation, DNA hyperexcision, and cGAS-STING-dependent apoptosis.
Sun X, Liu L, Wu C, Li X, Guo J, Zhang J, Guan J, Wang N, Gu L, Yang XW, Li GM.
Sun X, et al.
Proc Natl Acad Sci U S A. 2024 Mar 26;121(13):e2313652121. doi: 10.1073/pnas.2313652121. Epub 2024 Mar 18.
Proc Natl Acad Sci U S A. 2024.
PMID: 38498709
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Disease-related Huntingtin seeding activities in cerebrospinal fluids of Huntington's disease patients.
Lee CYD, Wang N, Shen K, Stricos M, Langfelder P, Cheon KH, Cortés EP, Vinters HV, Vonsattel JP, Wexler NS, Damoiseaux R, Frydman J, Yang XW.
Lee CYD, et al.
Sci Rep. 2020 Nov 20;10(1):20295. doi: 10.1038/s41598-020-77164-1.
Sci Rep. 2020.
PMID: 33219289
Free PMC article.
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PIAS1 modulates striatal transcription, DNA damage repair, and SUMOylation with relevance to Huntington's disease.
Morozko EL, Smith-Geater C, Monteys AM, Pradhan S, Lim RG, Langfelder P, Kachemov M, Kulkarni JA, Zaifman J, Hill A, Stocksdale JT, Cullis PR, Wu J, Ochaba J, Miramontes R, Chakraborty A, Hazra TK, Lau A, St-Cyr S, Orellana I, Kopan L, Wang KQ, Yeung S, Leavitt BR, Reidling JC, Yang XW, Steffan JS, Davidson BL, Sarkar PS, Thompson LM.
Morozko EL, et al.
Proc Natl Acad Sci U S A. 2021 Jan 26;118(4):e2021836118. doi: 10.1073/pnas.2021836118.
Proc Natl Acad Sci U S A. 2021.
PMID: 33468657
Free PMC article.
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