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ADRB2 haplotypes and asthma exacerbations in children and young adults: An individual participant data meta-analysis.
Karimi L, Vijverberg SJ, Engelkes M, Hernandez-Pacheco N, Farzan N, Soares P, Pino-Yanes M, Jorgensen AL, Eng C, Mukhopadhyay S, Schieck M, Kabesch M, Burchard EG, Chew FT, Sio YY, Potočnik U, Gorenjak M, Hawcutt DB, Palmer CN, Turner S, Janssens HM, Maitland-van der Zee AH, Verhamme KMC; PiCA and SysPharmPedia consortia. Karimi L, et al. Clin Exp Allergy. 2021 Sep;51(9):1157-1171. doi: 10.1111/cea.13965. Epub 2021 Jul 20. Clin Exp Allergy. 2021. PMID: 34128573 Free PMC article.
Identification of ROBO2 as a Potential Locus Associated with Inhaled Corticosteroid Response in Childhood Asthma.
Hernandez-Pacheco N, Gorenjak M, Li J, Repnik K, Vijverberg SJ, Berce V, Jorgensen A, Karimi L, Schieck M, Samedy-Bates LA, Tavendale R, Villar J, Mukhopadhyay S, Pirmohamed M, Verhamme KMC, Kabesch M, Hawcutt DB, Turner S, Palmer CN, Tantisira KG, Burchard EG, Maitland-van der Zee AH, Flores C, Potočnik U, Pino-Yanes M. Hernandez-Pacheco N, et al. J Pers Med. 2021 Jul 28;11(8):733. doi: 10.3390/jpm11080733. J Pers Med. 2021. PMID: 34442380 Free PMC article.
Patients with an improvement in lung function 8% were considered as ICS responders. Suggestively associated variants (p-value 5 10(-6)) were evaluated in an independent study (n = 175). ...As a result, the SNP rs1166980 from the ROBO2 gene was suggestively associated with …
Patients with an improvement in lung function 8% were considered as ICS responders. Suggestively associated variants (p-value 5 10(-6 …