R03 DA027113/DA/NIDA NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2013	4
2014	3
2015	2
2016	4
2017	1
2019	1
2022	1
2024	0

1

Leveraging allostery to improve G protein-coupled receptor (GPCR)-directed therapeutics: cannabinoid receptor 1 as discovery target.

Janero DR, Thakur GA. Janero DR, et al. Expert Opin Drug Discov. 2016 Dec;11(12):1223-1237. doi: 10.1080/17460441.2016.1245289. Epub 2016 Oct 21. Expert Opin Drug Discov. 2016. PMID: 27712124 Free PMC article. Review.

2

Negative allosteric modulation of CB₁ cannabinoid receptor signaling suppresses opioid-mediated reward.

Iyer V, Rangel-Barajas C, Woodward TJ, Kulkarni A, Cantwell L, Crystal JD, Mackie K, Rebec GV, Thakur GA, Hohmann AG. Iyer V, et al. Pharmacol Res. 2022 Nov;185:106474. doi: 10.1016/j.phrs.2022.106474. Epub 2022 Sep 28. Pharmacol Res. 2022. PMID: 36179954 Free PMC article.

3

Mapping Cannabinoid 1 Receptor Allosteric Site(s): Critical Molecular Determinant and Signaling Profile of GAT100, a Novel, Potent, and Irreversibly Binding Probe.

Laprairie RB, Kulkarni AR, Kulkarni PM, Hurst DP, Lynch D, Reggio PH, Janero DR, Pertwee RG, Stevenson LA, Kelly ME, Denovan-Wright EM, Thakur GA. Laprairie RB, et al. ACS Chem Neurosci. 2016 Jun 15;7(6):776-98. doi: 10.1021/acschemneuro.6b00041. Epub 2016 Apr 25. ACS Chem Neurosci. 2016. PMID: 27046127 Free PMC article.

4

Scalable, One-Pot, Microwave-Accelerated Tandem Synthesis of Unsymmetrical Urea Derivatives.

Kulkarni AR, Garai S, Thakur GA. Kulkarni AR, et al. J Org Chem. 2017 Jan 20;82(2):992-999. doi: 10.1021/acs.joc.6b02521. Epub 2016 Dec 30. J Org Chem. 2017. PMID: 27966953

5

Novel adamantyl cannabinoids as CB1 receptor probes.

Thakur GA, Bajaj S, Paronis C, Peng Y, Bowman AL, Barak LS, Caron MG, Parrish D, Deschamps JR, Makriyannis A. Thakur GA, et al. J Med Chem. 2013 May 23;56(10):3904-21. doi: 10.1021/jm4000775. Epub 2013 May 14. J Med Chem. 2013. PMID: 23621789 Free PMC article.

6

Positive allosteric modulation of the type 1 cannabinoid receptor reduces the signs and symptoms of Huntington's disease in the R6/2 mouse model.

Laprairie RB, Bagher AM, Rourke JL, Zrein A, Cairns EA, Kelly MEM, Sinal CJ, Kulkarni PM, Thakur GA, Denovan-Wright EM. Laprairie RB, et al. Neuropharmacology. 2019 Jun;151:1-12. doi: 10.1016/j.neuropharm.2019.03.033. Epub 2019 Mar 30. Neuropharmacology. 2019. PMID: 30940536 Free PMC article.

7

Novel Electrophilic and Photoaffinity Covalent Probes for Mapping the Cannabinoid 1 Receptor Allosteric Site(s).

Kulkarni PM, Kulkarni AR, Korde A, Tichkule RB, Laprairie RB, Denovan-Wright EM, Zhou H, Janero DR, Zvonok N, Makriyannis A, Cascio MG, Pertwee RG, Thakur GA. Kulkarni PM, et al. J Med Chem. 2016 Jan 14;59(1):44-60. doi: 10.1021/acs.jmedchem.5b01303. Epub 2015 Nov 28. J Med Chem. 2016. PMID: 26529344 Free PMC article.

8

In-vivo pharmacological evaluation of the CB1-receptor allosteric modulator Org-27569.

Gamage TF, Ignatowska-Jankowska BM, Wiley JL, Abdelrahman M, Trembleau L, Greig IR, Thakur GA, Tichkule R, Poklis J, Ross RA, Pertwee RG, Lichtman AH. Gamage TF, et al. Behav Pharmacol. 2014 Apr;25(2):182-5. doi: 10.1097/FBP.0000000000000027. Behav Pharmacol. 2014. PMID: 24603340 Free PMC article.

9

The analgesic-like properties of the alpha7 nAChR silent agonist NS6740 is associated with non-conducting conformations of the receptor.

Papke RL, Bagdas D, Kulkarni AR, Gould T, AlSharari SD, Thakur GA, Damaj MI. Papke RL, et al. Neuropharmacology. 2015 Apr;91:34-42. doi: 10.1016/j.neuropharm.2014.12.002. Epub 2014 Dec 11. Neuropharmacology. 2015. PMID: 25497451 Free PMC article.

10

Microwave-assisted Expeditious and Efficient Synthesis of Cyclopentene Ring-fused Tetrahydroquinoline Derivatives Using Three-component Povarov Reaction.

Kulkarni AR, Thakur GA. Kulkarni AR, et al. Tetrahedron Lett. 2013 Nov 27;54(48):10.1016/j.tetlet.2013.09.107. doi: 10.1016/j.tetlet.2013.09.107. Tetrahedron Lett. 2013. PMID: 24421568 Free PMC article.

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