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Improving coeliac disease risk prediction by testing non-HLA variants additional to HLA variants.
Romanos J, Rosén A, Kumar V, Trynka G, Franke L, Szperl A, Gutierrez-Achury J, van Diemen CC, Kanninga R, Jankipersadsing SA, Steck A, Eisenbarth G, van Heel DA, Cukrowska B, Bruno V, Mazzilli MC, Núñez C, Bilbao JR, Mearin ML, Barisani D, Rewers M, Norris JM, Ivarsson A, Boezen HM, Liu E, Wijmenga C; PreventCD Group. Romanos J, et al. Gut. 2014 Mar;63(3):415-22. doi: 10.1136/gutjnl-2012-304110. Epub 2013 May 23. Gut. 2014. PMID: 23704318 Free PMC article. Clinical Trial.
Contrasting the Genetic Background of Type 1 Diabetes and Celiac Disease Autoimmunity.
Gutierrez-Achury J, Romanos J, Bakker SF, Kumar V, de Haas EC, Trynka G, Ricaño-Ponce I, Steck A; Type 1 Diabetes Genetics Consortium; Chen WM, Onengut-Gumuscu S, Simsek S; Diabeter; Rewers M, Mulder CJ, Liu E, Rich SS, Wijmenga C. Gutierrez-Achury J, et al. Diabetes Care. 2015 Oct;38 Suppl 2(Suppl 2):S37-44. doi: 10.2337/dcs15-2007. Diabetes Care. 2015. PMID: 26405070 Free PMC article.
Tolerant anti-insulin B cells are effective APCs.
Kendall PL, Case JB, Sullivan AM, Holderness JS, Wells KS, Liu E, Thomas JW. Kendall PL, et al. J Immunol. 2013 Mar 15;190(6):2519-26. doi: 10.4049/jimmunol.1202104. Epub 2013 Feb 8. J Immunol. 2013. PMID: 23396943 Free PMC article.
Investigation of the vitamin D receptor gene (VDR) and its interaction with protein tyrosine phosphatase, non-receptor type 2 gene (PTPN2) on risk of islet autoimmunity and type 1 diabetes: the Diabetes Autoimmunity Study in the Young (DAISY).
Frederiksen B, Liu E, Romanos J, Steck AK, Yin X, Kroehl M, Fingerlin TE, Erlich H, Eisenbarth GS, Rewers M, Norris JM. Frederiksen B, et al. J Steroid Biochem Mol Biol. 2013 Jan;133:51-7. doi: 10.1016/j.jsbmb.2012.08.012. Epub 2012 Sep 7. J Steroid Biochem Mol Biol. 2013. PMID: 22960018 Free PMC article.