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Single-Nucleus Transcriptome Profiling of Dorsolateral Prefrontal Cortex: Mechanistic Roles for Neuronal Gene Expression, Including the 17q21.31 Locus, in PTSD Stress Response.
Chatzinakos C, Pernia CD, Morrison FG, Iatrou A, McCullough KM, Schuler H, Snijders C, Bajaj T, DiPietro CP, Soliva Estruch M, Gassen NC, Anastasopoulos C, Bharadwaj RA, Bowlby BC, Hartmann J, Maihofer AX, Nievergelt CM, Ressler NM, Wolf EJ; Traumatic Stress Brain Research Group; PTSD BrainOmics Project of the PsychENCODE Consortium; PTSD Working Group of the Psychiatric Genomics Consortium; Carlezon WA Jr, Krystal JH, Kleinman JE, Girgenti MJ, Huber BR, Kellis M, Logue MW, Miller MW, Ressler KJ, Daskalakis NP. Chatzinakos C, et al. Am J Psychiatry. 2023 Oct 1;180(10):739-754. doi: 10.1176/appi.ajp.20220478. Epub 2023 Jul 26. Am J Psychiatry. 2023. PMID: 37491937
From genetics to systems biology of stress-related mental disorders.
Dalvie S, Chatzinakos C, Al Zoubi O, Georgiadis F; PGC-PTSD Systems Biology workgroup; Lancashire L, Daskalakis NP. Dalvie S, et al. Neurobiol Stress. 2021 Sep 12;15:100393. doi: 10.1016/j.ynstr.2021.100393. eCollection 2021 Nov. Neurobiol Stress. 2021. PMID: 34584908 Free PMC article.
Increasing the resolution and precision of psychiatric genome-wide association studies by re-imputing summary statistics using a large, diverse reference panel.
Chatzinakos C, Lee D, Cai N, Vladimirov VI, Webb BT, Riley BP, Flint J, Kendler KS, Ressler KJ, Daskalakis NP, Bacanu SA. Chatzinakos C, et al. Am J Med Genet B Neuropsychiatr Genet. 2021 Jan;186(1):16-27. doi: 10.1002/ajmg.b.32834. Epub 2021 Feb 11. Am J Med Genet B Neuropsychiatr Genet. 2021. PMID: 33576176 Free PMC article. Review.
TWAS pathway method greatly enhances the number of leads for uncovering the molecular underpinnings of psychiatric disorders.
Chatzinakos C, Georgiadis F, Lee D, Cai N, Vladimirov VI, Docherty A, Webb BT, Riley BP, Flint J, Kendler KS, Daskalakis NP, Bacanu SA. Chatzinakos C, et al. Am J Med Genet B Neuropsychiatr Genet. 2020 Dec;183(8):454-463. doi: 10.1002/ajmg.b.32823. Epub 2020 Sep 21. Am J Med Genet B Neuropsychiatr Genet. 2020. PMID: 32954640 Free PMC article.