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Dissecting the immune suppressive human prostate tumor microenvironment via integrated single-cell and spatial transcriptomic analyses.
Hirz T, Mei S, Sarkar H, Kfoury Y, Wu S, Verhoeven BM, Subtelny AO, Zlatev DV, Wszolek MW, Salari K, Murray E, Chen F, Macosko EZ, Wu CL, Scadden DT, Dahl DM, Baryawno N, Saylor PJ, Kharchenko PV, Sykes DB. Hirz T, et al. Nat Commun. 2023 Feb 7;14(1):663. doi: 10.1038/s41467-023-36325-2. Nat Commun. 2023. PMID: 36750562 Free PMC article.
Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment.
Kfoury Y, Baryawno N, Severe N, Mei S, Gustafsson K, Hirz T, Brouse T, Scadden EW, Igolkina AA, Kokkaliaris K, Choi BD, Barkas N, Randolph MA, Shin JH, Saylor PJ, Scadden DT, Sykes DB, Kharchenko PV; as part of the Boston Bone Metastases Consortium. Kfoury Y, et al. Cancer Cell. 2021 Nov 8;39(11):1464-1478.e8. doi: 10.1016/j.ccell.2021.09.005. Epub 2021 Oct 15. Cancer Cell. 2021. PMID: 34719426 Free PMC article.
Heterogeneity of the bone marrow niche.
Yu VW, Scadden DT. Yu VW, et al. Curr Opin Hematol. 2016 Jul;23(4):331-8. doi: 10.1097/MOH.0000000000000265. Curr Opin Hematol. 2016. PMID: 27177311 Free PMC article. Review.
Intravital fluorescence microscopy with negative contrast.
Wu JW, Jung Y, Yeh SA, Seo Y, Runnels JM, Burns CS, Mizoguchi T, Ito K, Spencer JA, Lin CP. Wu JW, et al. PLoS One. 2021 Aug 5;16(8):e0255204. doi: 10.1371/journal.pone.0255204. eCollection 2021. PLoS One. 2021. PMID: 34351959 Free PMC article.
Live-animal imaging of native haematopoietic stem and progenitor cells.
Christodoulou C, Spencer JA, Yeh SA, Turcotte R, Kokkaliaris KD, Panero R, Ramos A, Guo G, Seyedhassantehrani N, Esipova TV, Vinogradov SA, Rudzinskas S, Zhang Y, Perkins AS, Orkin SH, Calogero RA, Schroeder T, Lin CP, Camargo FD. Christodoulou C, et al. Nature. 2020 Feb;578(7794):278-283. doi: 10.1038/s41586-020-1971-z. Epub 2020 Feb 5. Nature. 2020. PMID: 32025033 Free PMC article.
Stress-Induced Changes in Bone Marrow Stromal Cell Populations Revealed through Single-Cell Protein Expression Mapping.
Severe N, Karabacak NM, Gustafsson K, Baryawno N, Courties G, Kfoury Y, Kokkaliaris KD, Rhee C, Lee D, Scadden EW, Garcia-Robledo JE, Brouse T, Nahrendorf M, Toner M, Scadden DT. Severe N, et al. Cell Stem Cell. 2019 Oct 3;25(4):570-583.e7. doi: 10.1016/j.stem.2019.06.003. Epub 2019 Jul 3. Cell Stem Cell. 2019. PMID: 31279774 Free PMC article.