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Optimization of Orally Bioavailable Antileishmanial 2,4,5-Trisubstituted Benzamides.
Kim HS, Ortiz D, Kadayat TM, Fargo CM, Hammill JT, Chen Y, Rice AL, Begley KL, Shoeran G, Pistel W, Yates PA, Sanchez MA, Landfear SM, Guy RK. Kim HS, et al. J Med Chem. 2023 Jun 8;66(11):7374-7386. doi: 10.1021/acs.jmedchem.3c00056. Epub 2023 May 22. J Med Chem. 2023. PMID: 37216489 Free PMC article.
Amino-Substituted 3-Aryl- and 3-Heteroarylquinolines as Potential Antileishmanial Agents.
Hammill JT, Sviripa VM, Kril LM, Ortiz D, Fargo CM, Kim HS, Chen Y, Rector J, Rice AL, Domagalska MA, Begley KL, Liu C, Rangnekar VM, Dujardin JC, Watt DS, Landfear SM, Guy RK. Hammill JT, et al. J Med Chem. 2021 Aug 26;64(16):12152-12162. doi: 10.1021/acs.jmedchem.1c00813. Epub 2021 Aug 6. J Med Chem. 2021. PMID: 34355566 Free PMC article.
Discovery of novel, orally bioavailable, antileishmanial compounds using phenotypic screening.
Ortiz D, Guiguemde WA, Hammill JT, Carrillo AK, Chen Y, Connelly M, Stalheim K, Elya C, Johnson A, Min J, Shelat A, Smithson DC, Yang L, Zhu F, Guy RK, Landfear SM. Ortiz D, et al. PLoS Negl Trop Dis. 2017 Dec 29;11(12):e0006157. doi: 10.1371/journal.pntd.0006157. eCollection 2017 Dec. PLoS Negl Trop Dis. 2017. PMID: 29287089 Free PMC article.