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A plasmid system with tunable copy number.
Rouches MV, Xu Y, Cortes LBG, Lambert G. Rouches MV, et al. Nat Commun. 2022 Jul 7;13(1):3908. doi: 10.1038/s41467-022-31422-0. Nat Commun. 2022. PMID: 35798738 Free PMC article.
Polarity of the CRISPR roadblock to transcription.
Hall PM, Inman JT, Fulbright RM, Le TT, Brewer JJ, Lambert G, Darst SA, Wang MD. Hall PM, et al. Nat Struct Mol Biol. 2022 Dec;29(12):1217-1227. doi: 10.1038/s41594-022-00864-x. Epub 2022 Dec 5. Nat Struct Mol Biol. 2022. PMID: 36471058 Free PMC article.
Increased energy demand from anabolic-catabolic processes drives β-lactam antibiotic lethality.
Lobritz MA, Andrews IW, Braff D, Porter CBM, Gutierrez A, Furuta Y, Cortes LBG, Ferrante T, Bening SC, Wong F, Gruber C, Bakerlee CW, Lambert G, Walker GC, Dwyer DJ, Collins JJ. Lobritz MA, et al. Cell Chem Biol. 2022 Feb 17;29(2):276-286.e4. doi: 10.1016/j.chembiol.2021.12.010. Epub 2022 Jan 5. Cell Chem Biol. 2022. PMID: 34990601 Free PMC article.