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Page 1
Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism.
Lindström S, Wang L, Smith EN, Gordon W, van Hylckama Vlieg A, de Andrade M, Brody JA, Pattee JW, Haessler J, Brumpton BM, Chasman DI, Suchon P, Chen MH, Turman C, Germain M, Wiggins KL, MacDonald J, Braekkan SK, Armasu SM, Pankratz N, Jackson RD, Nielsen JB, Giulianini F, Puurunen MK, Ibrahim M, Heckbert SR, Damrauer SM, Natarajan P, Klarin D; Million Veteran Program; de Vries PS, Sabater-Lleal M, Huffman JE; CHARGE Hemostasis Working Group; Bammler TK, Frazer KA, McCauley BM, Taylor K, Pankow JS, Reiner AP, Gabrielsen ME, Deleuze JF, O'Donnell CJ, Kim J, McKnight B, Kraft P, Hansen JB, Rosendaal FR, Heit JA, Psaty BM, Tang W, Kooperberg C, Hveem K, Ridker PM, Morange PE, Johnson AD, Kabrhel C, Trégouët DA, Smith NL. Lindström S, et al. Blood. 2019 Nov 7;134(19):1645-1657. doi: 10.1182/blood.2019000435. Blood. 2019. PMID: 31420334 Free PMC article.
Estrogen activates endothelial exocytosis.
Kim CS, Yea K, Morrell CN, Jeong Y, Lowenstein CJ. Kim CS, et al. Biochem Biophys Res Commun. 2021 Jun 18;558:29-35. doi: 10.1016/j.bbrc.2021.04.019. Epub 2021 Apr 22. Biochem Biophys Res Commun. 2021. PMID: 33895548 Free PMC article.
Acetylcholine Inhibits Platelet Activation.
Bennett JA, Ture SK, Schmidt RA, Mastrangelo MA, Cameron SJ, Terry LE, Yule DI, Morrell CN, Lowenstein CJ. Bennett JA, et al. J Pharmacol Exp Ther. 2019 May;369(2):182-187. doi: 10.1124/jpet.118.253583. Epub 2019 Feb 14. J Pharmacol Exp Ther. 2019. PMID: 30765424 Free PMC article.
The choline transporter Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function.
Bennett JA, Mastrangelo MA, Ture SK, Smith CO, Loelius SG, Berg RA, Shi X, Burke RM, Spinelli SL, Cameron SJ, Carey TE, Brookes PS, Gerszten RE, Sabater-Lleal M, de Vries PS, Huffman JE, Smith NL, Morrell CN, Lowenstein CJ. Bennett JA, et al. Nat Commun. 2020 Jul 13;11(1):3479. doi: 10.1038/s41467-020-17254-w. Nat Commun. 2020. PMID: 32661250 Free PMC article.