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Matrix metalloproteinase-19 is a key regulator of lung fibrosis in mice and humans.
Yu G, Kovkarova-Naumovski E, Jara P, Parwani A, Kass D, Ruiz V, Lopez-Otín C, Rosas IO, Gibson KF, Cabrera S, Ramírez R, Yousem SA, Richards TJ, Chensny LJ, Selman M, Kaminski N, Pardo A. Yu G, et al. Am J Respir Crit Care Med. 2012 Oct 15;186(8):752-62. doi: 10.1164/rccm.201202-0302OC. Epub 2012 Aug 2. Am J Respir Crit Care Med. 2012. PMID: 22859522 Free PMC article.
Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis.
Takiar V, Nishio S, Seo-Mayer P, King JD Jr, Li H, Zhang L, Karihaloo A, Hallows KR, Somlo S, Caplan MJ. Takiar V, et al. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2462-7. doi: 10.1073/pnas.1011498108. Epub 2011 Jan 24. Proc Natl Acad Sci U S A. 2011. PMID: 21262823 Free PMC article.