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Examination of Metoprolol Pharmacokinetics and Pharmacodynamics Across CYP2D6 Genotype-Derived Activity Scores.
Thomas CD, Mosley SA, Kim S, Lingineni K, El Rouby N, Langaee TY, Gong Y, Wang D, Schmidt SO, Binkley PF, Estores DS, Feng K, Kim H, Kinjo M, Li Z, Fang L, Chapman AB, Cooper-DeHoff RM, Gums JG, Hamadeh IS, Zhao L, Schmidt S, Frye RF, Johnson JA, Cavallari LH. Thomas CD, et al. CPT Pharmacometrics Syst Pharmacol. 2020 Dec;9(12):678-685. doi: 10.1002/psp4.12563. Epub 2020 Nov 3. CPT Pharmacometrics Syst Pharmacol. 2020. PMID: 33067866 Free PMC article. Clinical Trial.
A randomized, cross-over trial of metoprolol succinate formulations to evaluate PK and PD end points for therapeutic equivalence.
Mosley SA, Kim S, El Rouby N, Lingineni K, Esteban VV, Gong Y, Chen Y, Estores D, Feng K, Kim H, Kinjo M, Langaee T, Li Z, Schmidt SOF, Johnson JA, Frye RF, Fang LL, Zhao L, Binkley PF, Schmidt S, Cavallari LH. Mosley SA, et al. Clin Transl Sci. 2022 Jul;15(7):1764-1775. doi: 10.1111/cts.13294. Epub 2022 May 21. Clin Transl Sci. 2022. PMID: 35488487 Free PMC article. Clinical Trial.