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2024 | 1 |
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CXCR4-targeted nanotoxins induce GSDME-dependent pyroptosis in head and neck squamous cell carcinoma.
J Exp Clin Cancer Res. 2022 Feb 4;41(1):49. doi: 10.1186/s13046-022-02267-8.
J Exp Clin Cancer Res. 2022.
PMID: 35120582
Free PMC article.
Thus, novel therapeutic strategies are urgently needed. Targeted drug delivery to the chemokine receptor 4 (CXCR4) represents a promising approach for HNSCC management. In this context, we have developed the self-assembling protein nanotoxins T22-PE24-H6 and T22-DITOX-H6, …
Thus, novel therapeutic strategies are urgently needed. Targeted drug delivery to the chemokine receptor 4 (CXCR4) represents a promi …
Structural Stabilization of Clinically Oriented Oligomeric Proteins During their Transit through Synthetic Secretory Amyloids.
Sánchez JM, López-Laguna H, Parladé E, Somma AD, Livieri AL, Álamo P, Mangues R, Unzueta U, Villaverde A, Vázquez E.
Sánchez JM, et al.
Adv Sci (Weinh). 2024 Mar 19:e2309427. doi: 10.1002/advs.202309427. Online ahead of print.
Adv Sci (Weinh). 2024.
PMID: 38501900
Developing time-sustained drug delivery systems is a main goal in innovative medicines. Inspired by the architecture of secretory granules from the mammalian endocrine system it has generated non-toxic microscale amyloid materials through the coordination between divalent …
Developing time-sustained drug delivery systems is a main goal in innovative medicines. Inspired by the architecture of secretory gra …
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