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Page 1
2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer.
Blomme A, Ford CA, Mui E, Patel R, Ntala C, Jamieson LE, Planque M, McGregor GH, Peixoto P, Hervouet E, Nixon C, Salji M, Gaughan L, Markert E, Repiscak P, Sumpton D, Blanco GR, Lilla S, Kamphorst JJ, Graham D, Faulds K, MacKay GM, Fendt SM, Zanivan S, Leung HY. Blomme A, et al. Nat Commun. 2020 May 19;11(1):2508. doi: 10.1038/s41467-020-16126-7. Nat Commun. 2020. PMID: 32427840 Free PMC article.
Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments.
Peck B, Schug ZT, Zhang Q, Dankworth B, Jones DT, Smethurst E, Patel R, Mason S, Jiang M, Saunders R, Howell M, Mitter R, Spencer-Dene B, Stamp G, McGarry L, James D, Shanks E, Aboagye EO, Critchlow SE, Leung HY, Harris AL, Wakelam MJO, Gottlieb E, Schulze A. Peck B, et al. Cancer Metab. 2016 Apr 1;4:6. doi: 10.1186/s40170-016-0146-8. eCollection 2016. Cancer Metab. 2016. PMID: 27042297 Free PMC article.
The androgen receptor controls expression of the cancer-associated sTn antigen and cell adhesion through induction of ST6GalNAc1 in prostate cancer.
Munkley J, Oltean S, Vodák D, Wilson BT, Livermore KE, Zhou Y, Star E, Floros VI, Johannessen B, Knight B, McCullagh P, McGrath J, Crundwell M, Skotheim RI, Robson CN, Leung HY, Harries LW, Rajan P, Mills IG, Elliott DJ. Munkley J, et al. Oncotarget. 2015 Oct 27;6(33):34358-74. doi: 10.18632/oncotarget.6024. Oncotarget. 2015. PMID: 26452038 Free PMC article.
Feasibility study of a randomized controlled trial comparing docetaxel chemotherapy and androgen deprivation therapy with sequential prostatic biopsies from patients with advanced non-castration-resistant prostate cancer.
Rajan P, Frew JA, Wilson JM, Azzabi AS, McMenemin RM, Stockley J, Soomro NA, Durkan G, Pedley ID, Leung HY. Rajan P, et al. Urol Oncol. 2015 Aug;33(8):337.e1-6. doi: 10.1016/j.urolonc.2015.05.012. Epub 2015 Jun 16. Urol Oncol. 2015. PMID: 26092557 Clinical Trial.
AMPK-friend or foe for targeted therapy?
Choudhury Y, Salt IP, Leung HY. Choudhury Y, et al. Cell Cycle. 2015;14(12):1761-2. doi: 10.1080/15384101.2015.1022066. Cell Cycle. 2015. PMID: 26036305 Free PMC article. No abstract available.
40 results