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Page 1
Showing results for abeta y
Search for Abetu Y instead (3 results)
Salidroside attenuates neuronal ferroptosis by activating the Nrf2/HO1 signaling pathway in Abeta(1-42)-induced Alzheimer's disease mice and glutamate-injured HT22 cells.
Yang S, Xie Z, Pei T, Zeng Y, Xiong Q, Wei H, Wang Y, Cheng W. Yang S, et al. Chin Med. 2022 Jul 4;17(1):82. doi: 10.1186/s13020-022-00634-3. Chin Med. 2022. PMID: 35787281 Free PMC article.
Malondialdehyde, reduced glutathione, oxidized glutathione disulfide, and superoxide dismutase were measured. The novel object recognition test, Y-maze, and open field test were used to investigate the protective effects of salidroside on Abeta(1-42)-induced WT and …
Malondialdehyde, reduced glutathione, oxidized glutathione disulfide, and superoxide dismutase were measured. The novel object recognition t …
Gossypetin ameliorates 5xFAD spatial learning and memory through enhanced phagocytosis against Abeta.
Jo KW, Lee D, Cha DG, Oh E, Choi YH, Kim S, Park ES, Kim JK, Kim KT. Jo KW, et al. Alzheimers Res Ther. 2022 Oct 21;14(1):158. doi: 10.1186/s13195-022-01096-3. Alzheimers Res Ther. 2022. PMID: 36271414 Free PMC article.
Microglia constantly scavenge various waste materials in the brain including damaged or apoptotic neurons and Abeta. Through phagocytosis of Abeta, microglia prevent the accumulation of Abeta plaque in the brain. ...Since microglia play an important role in …
Microglia constantly scavenge various waste materials in the brain including damaged or apoptotic neurons and Abeta. Through phagocyt …
Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer's Disease.
Friedli MJ, Inestrosa NC. Friedli MJ, et al. Molecules. 2021 Oct 29;26(21):6531. doi: 10.3390/molecules26216531. Molecules. 2021. PMID: 34770940 Free PMC article. Review.
Here, we summarize the neuroprotective effects of HupA on AD, with an emphasis on its interactions with different molecular signaling avenues, such as the Wnt signaling, the pre- and post-synaptic region mechanisms (synaptotagmin, neuroligins), the amyloid precursor protein (APP) …
Here, we summarize the neuroprotective effects of HupA on AD, with an emphasis on its interactions with different molecular signaling avenue …
The S1P receptor 1 antagonist Ponesimod reduces TLR4-induced neuroinflammation and increases Abeta clearance in 5XFAD mice.
Zhu Z, Zhang L, Elsherbini A, Crivelli SM, Tripathi P, Harper C, Quadri Z, Spassieva SD, Bieberich E. Zhu Z, et al. EBioMedicine. 2023 Aug;94:104713. doi: 10.1016/j.ebiom.2023.104713. Epub 2023 Jul 20. EBioMedicine. 2023. PMID: 37480622 Free PMC article.
FINDINGS: Abeta(42) increased the levels of TLR4 and S1PR1, leading to their complex formation. ...It also increased the level of IL-33, an anti-inflammatory cytokine that promotes Abeta(42) phagocytosis by microglia. As a result of these changes, Ponesimod decrease …
FINDINGS: Abeta(42) increased the levels of TLR4 and S1PR1, leading to their complex formation. ...It also increased the level of IL- …
The VCAM1-ApoE pathway directs microglial chemotaxis and alleviates Alzheimer's disease pathology.
Lau SF, Wu W, Wong HY, Ouyang L, Qiao Y, Xu J, Lau JH, Wong C, Jiang Y, Holtzman DM, Fu AKY, Ip NY. Lau SF, et al. Nat Aging. 2023 Oct;3(10):1219-1236. doi: 10.1038/s43587-023-00491-1. Epub 2023 Sep 21. Nat Aging. 2023. PMID: 37735240 Free PMC article.
Here, we show that IL-33 induces VCAM1 in microglia, which promotes microglial chemotaxis toward amyloid-beta (Abeta) plaque-associated ApoE, and leads to Abeta clearance. We show that IL-33 stimulates a chemotactic state in microglia, characterized by Abeta- …
Here, we show that IL-33 induces VCAM1 in microglia, which promotes microglial chemotaxis toward amyloid-beta (Abeta) plaque-associat …
Abeta(1-42) peptides blunt the adenosine A(2A) receptor-mediated control of the interplay between P(2)X(7) and P(2)Y(1) receptors mediated calcium responses in astrocytes.
Dias L, Madeira D, Dias R, Tomé ÂR, Cunha RA, Agostinho P. Dias L, et al. Cell Mol Life Sci. 2022 Jul 30;79(8):457. doi: 10.1007/s00018-022-04492-y. Cell Mol Life Sci. 2022. PMID: 35907034 Free PMC article.
In primary cultures of rat astrocytes exposed to Abeta(1-42), ATP-evoked Ca(2+) responses had a lower amplitude but a longer duration than in control astrocytes and involved P(2)X(7)R and P(2)Y(1)R, the former potentiating the later. Moreover, Abeta(1-42) exp …
In primary cultures of rat astrocytes exposed to Abeta(1-42), ATP-evoked Ca(2+) responses had a lower amplitude but a longer duration …
Inflammation context in Alzheimer's disease, a relationship intricate to define.
Novoa C, Salazar P, Cisternas P, Gherardelli C, Vera-Salazar R, Zolezzi JM, Inestrosa NC. Novoa C, et al. Biol Res. 2022 Dec 23;55(1):39. doi: 10.1186/s40659-022-00404-3. Biol Res. 2022. PMID: 36550479 Free PMC article. Review.
Alzheimer's disease (AD), the most common form of dementia, is characterized by the accumulation of amyloid beta (Abeta) and hyperphosphorylated tau protein aggregates. Importantly, Abeta and tau species are able to activate astrocytes and microglia, which release s …
Alzheimer's disease (AD), the most common form of dementia, is characterized by the accumulation of amyloid beta (Abeta) and hyperpho …
Abeta and tau prions feature in the neuropathogenesis of Down syndrome.
Condello C, Maxwell AM, Castillo E, Aoyagi A, Graff C, Ingelsson M, Lannfelt L, Bird TD, Keene CD, Seeley WW, Perl DP, Head E, Prusiner SB. Condello C, et al. Proc Natl Acad Sci U S A. 2022 Nov 16;119(46):e2212954119. doi: 10.1073/pnas.2212954119. Epub 2022 Nov 7. Proc Natl Acad Sci U S A. 2022. PMID: 36343257 Free PMC article.
In brain extracts from 28 deceased donors with DS, ranging in age from 19 to 65 y, we found nearly all DS brains had readily measurable levels of Abeta and tau prions. In a cross-sectional analysis of DS donor age at death, we found that the levels of Abeta a …
In brain extracts from 28 deceased donors with DS, ranging in age from 19 to 65 y, we found nearly all DS brains had readily measurab …
The Role of Circulating Abeta Seeds in the Progression of Cerebral Amyloidosis.
Gamez N, Morales R. Gamez N, et al. Neurosci Insights. 2022 Sep 15;17:26331055221123072. doi: 10.1177/26331055221123072. eCollection 2022. Neurosci Insights. 2022. PMID: 36158163 Free PMC article.
The peripheral sink hypothesis postulates that the central and peripheral pools of Abeta co-exist in equilibrium. As such, cerebral amyloid levels may be modulated by intervening circulating Abeta. ...Finally, we discuss the implications of targeting peripheral A …
The peripheral sink hypothesis postulates that the central and peripheral pools of Abeta co-exist in equilibrium. As such, cerebral a …
The Y(682)ENPTY(687) motif of APP: Progress and insights toward a targeted therapy for Alzheimer's disease patients.
Matrone C, Iannuzzi F, Annunziato L. Matrone C, et al. Ageing Res Rev. 2019 Jul;52:120-128. doi: 10.1016/j.arr.2019.04.003. Epub 2019 Apr 27. Ageing Res Rev. 2019. PMID: 31039414 Review.
As such, modern pharmacologic approaches are largely based on reducing production by inhibiting beta and gamma secretase cleavage of the amyloid precursor protein (APP) or on dissolving existing cerebral Abeta plaques or to favor Abeta clearance from the brain. The …
As such, modern pharmacologic approaches are largely based on reducing production by inhibiting beta and gamma secretase cleavage of the amy …
1,649 results