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Dominant Mutations in the Autoimmune Regulator AIRE Are Associated with Common Organ-Specific Autoimmune Diseases.
Oftedal BE, Hellesen A, Erichsen MM, Bratland E, Vardi A, Perheentupa J, Kemp EH, Fiskerstrand T, Viken MK, Weetman AP, Fleishman SJ, Banka S, Newman WG, Sewell WA, Sozaeva LS, Zayats T, Haugarvoll K, Orlova EM, Haavik J, Johansson S, Knappskog PM, Løvås K, Wolff AS, Abramson J, Husebye ES. Oftedal BE, et al. Among authors: abramson j. Immunity. 2015 Jun 16;42(6):1185-96. doi: 10.1016/j.immuni.2015.04.021. Immunity. 2015. PMID: 26084028 Free article.
Mechanistic dissection of dominant AIRE mutations in mouse models reveals AIRE autoregulation.
Goldfarb Y, Givony T, Kadouri N, Dobeš J, Peligero-Cruz C, Zalayat I, Damari G, Dassa B, Ben-Dor S, Gruper Y, Oftedal BE, Bratland E, Erichsen MM, Berger A, Avin A, Nevo S, Haljasorg U, Kuperman Y, Ulman A, Haffner-Krausz R, Porat Z, Atasoy U, Leshkowitz D, Husebye ES, Abramson J. Goldfarb Y, et al. Among authors: abramson j. J Exp Med. 2021 Nov 1;218(11):e20201076. doi: 10.1084/jem.20201076. Epub 2021 Sep 3. J Exp Med. 2021. PMID: 34477806 Free PMC article.
Extrathymic expression of Aire controls the induction of effective TH17 cell-mediated immune response to Candida albicans.
Dobeš J, Ben-Nun O, Binyamin A, Stoler-Barak L, Oftedal BE, Goldfarb Y, Kadouri N, Gruper Y, Givony T, Zalayat I, Kováčová K, Böhmová H, Valter E, Shulman Z, Filipp D, Husebye ES, Abramson J. Dobeš J, et al. Among authors: abramson j. Nat Immunol. 2022 Jul;23(7):1098-1108. doi: 10.1038/s41590-022-01247-6. Epub 2022 Jun 27. Nat Immunol. 2022. PMID: 35761088
Autoimmune amelogenesis imperfecta in patients with APS-1 and coeliac disease.
Gruper Y, Wolff ASB, Glanz L, Spoutil F, Marthinussen MC, Osickova A, Herzig Y, Goldfarb Y, Aranaz-Novaliches G, Dobeš J, Kadouri N, Ben-Nun O, Binyamin A, Lavi B, Givony T, Khalaila R, Gome T, Wald T, Mrazkova B, Sochen C, Besnard M, Ben-Dor S, Feldmesser E, Orlova EM, Hegedűs C, Lampé I, Papp T, Felszeghy S, Sedlacek R, Davidovich E, Tal N, Shouval DS, Shamir R, Guillonneau C, Szondy Z, Lundin KEA, Osicka R, Prochazka J, Husebye ES, Abramson J. Gruper Y, et al. Among authors: abramson j. Nature. 2023 Dec;624(7992):653-662. doi: 10.1038/s41586-023-06776-0. Epub 2023 Nov 22. Nature. 2023. PMID: 37993717
Transcriptional programs that control expression of the autoimmune regulator gene Aire.
Herzig Y, Nevo S, Bornstein C, Brezis MR, Ben-Hur S, Shkedy A, Eisenberg-Bord M, Levi B, Delacher M, Goldfarb Y, David E, Weinberger L, Viukov S, Ben-Dor S, Giraud M, Hanna JH, Breiling A, Lyko F, Amit I, Feuerer M, Abramson J. Herzig Y, et al. Among authors: abramson j. Nat Immunol. 2017 Feb;18(2):161-172. doi: 10.1038/ni.3638. Epub 2016 Dec 12. Nat Immunol. 2017. PMID: 27941786
Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity.
Koh AS, Kuo AJ, Park SY, Cheung P, Abramson J, Bua D, Carney D, Shoelson SE, Gozani O, Kingston RE, Benoist C, Mathis D. Koh AS, et al. Among authors: abramson j. Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15878-83. doi: 10.1073/pnas.0808470105. Epub 2008 Oct 7. Proc Natl Acad Sci U S A. 2008. PMID: 18840680 Free PMC article.
714 results