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Hypermutable non-synonymous sites are under stronger negative selection.
Schmidt S, Gerasimova A, Kondrashov FA, Adzhubei IA, Adzuhbei IA, Kondrashov AS, Sunyaev S. Schmidt S, et al. Among authors: adzuhbei ia. PLoS Genet. 2008 Nov;4(11):e1000281. doi: 10.1371/journal.pgen.1000281. Epub 2008 Nov 28. PLoS Genet. 2008. PMID: 19043566 Free PMC article.