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Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium.
Pettersen EO, Ebbesen P, Gieling RG, Williams KJ, Dubois L, Lambin P, Ward C, Meehan J, Kunkler IH, Langdon SP, Ree AH, Flatmark K, Lyng H, Calzada MJ, Peso LD, Landazuri MO, Görlach A, Flamm H, Kieninger J, Urban G, Weltin A, Singleton DC, Haider S, Buffa FM, Harris AL, Scozzafava A, Supuran CT, Moser I, Jobst G, Busk M, Toustrup K, Overgaard J, Alsner J, Pouyssegur J, Chiche J, Mazure N, Marchiq I, Parks S, Ahmed A, Ashcroft M, Pastorekova S, Cao Y, Rouschop KM, Wouters BG, Koritzinsky M, Mujcic H, Cojocari D. Pettersen EO, et al. Among authors: ahmed a. J Enzyme Inhib Med Chem. 2015;30(5):689-721. doi: 10.3109/14756366.2014.966704. Epub 2014 Oct 27. J Enzyme Inhib Med Chem. 2015. PMID: 25347767 Review.
TRP-ing off the p53 apoptotic switch.
Ahmed A, Ashcroft M. Ahmed A, et al. Pigment Cell Melanoma Res. 2010 Oct;23(5):581-2. doi: 10.1111/j.1755-148X.2010.00747.x. Pigment Cell Melanoma Res. 2010. PMID: 20840120 No abstract available.
TRP-ing off the p53 apoptotic switch.
Ahmed A, Ashcroft M. Ahmed A, et al. Pigment Cell Melanoma Res. 2010 Jul 29. doi: 10.1111/j.1755-1471.2010.00746.x. Online ahead of print. Pigment Cell Melanoma Res. 2010. PMID: 20673277 No abstract available.
Human CHCHD4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia signaling and tumor progression.
Yang J, Staples O, Thomas LW, Briston T, Robson M, Poon E, Simões ML, El-Emir E, Buffa FM, Ahmed A, Annear NP, Shukla D, Pedley BR, Maxwell PH, Harris AL, Ashcroft M. Yang J, et al. Among authors: ahmed a. J Clin Invest. 2012 Feb;122(2):600-11. doi: 10.1172/JCI58780. Epub 2012 Jan 3. J Clin Invest. 2012. PMID: 22214851 Free PMC article.
Small-molecule activation of p53 blocks hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in vivo and leads to tumor cell apoptosis in normoxia and hypoxia.
Yang J, Ahmed A, Poon E, Perusinghe N, de Haven Brandon A, Box G, Valenti M, Eccles S, Rouschop K, Wouters B, Ashcroft M. Yang J, et al. Among authors: ahmed a. Mol Cell Biol. 2009 Apr;29(8):2243-53. doi: 10.1128/MCB.00959-08. Epub 2009 Feb 17. Mol Cell Biol. 2009. PMID: 19223463 Free PMC article.
Activation of a unique p53-dependent DNA damage response.
Yang J, Ahmed A, Ashcroft M. Yang J, et al. Among authors: ahmed a. Cell Cycle. 2009 May 15;8(10):1630-2. doi: 10.4161/cc.8.10.8326. Epub 2009 May 2. Cell Cycle. 2009. PMID: 19372763 No abstract available.
The synthesis and structure revision of NSC-134754.
Hickin JA, Ahmed A, Fucke K, Ashcroft M, Jones K. Hickin JA, et al. Among authors: ahmed a. Chem Commun (Camb). 2014 Feb 7;50(10):1238-40. doi: 10.1039/c3cc48189a. Chem Commun (Camb). 2014. PMID: 24336320
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