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Potent cyclic peptide inhibitors of VLA-4 (alpha4beta1 integrin)-mediated cell adhesion. Discovery of compounds like cyclo(MePhe-Leu-Asp-Val-D-Arg-D-Arg) (ZD7349) compatible with depot formulation.
J Pept Sci. 2000 Aug;6(8):398-412. doi: 10.1002/1099-1387(200008)6:8<398::AID-PSC270>3.0.CO;2-1.
J Pept Sci. 2000.
PMID: 10969869
Anti-inflammatory activity of c(ILDV-NH(CH2)5CO), a novel, selective, cyclic peptide inhibitor of VLA-4-mediated cell adhesion.
Haworth D, Rees A, Alcock PJ, Wood LJ, Dutta AS, Gormley JJ, Jones HB, Jamieson A, Reilly CF.
Haworth D, et al. Among authors: alcock pj.
Br J Pharmacol. 1999 Apr;126(8):1751-60. doi: 10.1038/sj.bjp.0702511.
Br J Pharmacol. 1999.
PMID: 10372817
Free PMC article.
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Potent cyclic monomeric and dimeric peptide inhibitors of VLA-4 (alpha4beta1 integrin)-mediated cell adhesion based on the Ile-Leu-Asp-Val tetrapeptide.
Dutta AS, Crowther M, Gormley JJ, Hassall L, Hayward CF, Gellert PR, Kittlety RS, Alcock PJ, Jamieson A, Moores JM, Rees A, Wood LJ, Reilly CF, Haworth D.
Dutta AS, et al. Among authors: alcock pj.
J Pept Sci. 2000 Jul;6(7):321-41. doi: 10.1002/1099-1387(200007)6:7<321::AID-PSC259>3.0.CO;2-A.
J Pept Sci. 2000.
PMID: 10946997
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Discovery of Imidazo[1,2-a]pyridine Ethers and Squaramides as Selective and Potent Inhibitors of Mycobacterial Adenosine Triphosphate (ATP) Synthesis.
Tantry SJ, Markad SD, Shinde V, Bhat J, Balakrishnan G, Gupta AK, Ambady A, Raichurkar A, Kedari C, Sharma S, Mudugal NV, Narayan A, Naveen Kumar CN, Nanduri R, Bharath S, Reddy J, Panduga V, Prabhakar KR, Kandaswamy K, Saralaya R, Kaur P, Dinesh N, Guptha S, Rich K, Murray D, Plant H, Preston M, Ashton H, Plant D, Walsh J, Alcock P, Naylor K, Collier M, Whiteaker J, McLaughlin RE, Mallya M, Panda M, Rudrapatna S, Ramachandran V, Shandil R, Sambandamurthy VK, Mdluli K, Cooper CB, Rubin H, Yano T, Iyer P, Narayanan S, Kavanagh S, Mukherjee K, Balasubramanian V, Hosagrahara VP, Solapure S, Ravishankar S, Hameed P S.
Tantry SJ, et al.
J Med Chem. 2017 Feb 23;60(4):1379-1399. doi: 10.1021/acs.jmedchem.6b01358. Epub 2017 Feb 3.
J Med Chem. 2017.
PMID: 28075132
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ICI 204448: a kappa-opioid agonist with limited access to the CNS.
Shaw JS, Carroll JA, Alcock P, Main BG.
Shaw JS, et al.
Br J Pharmacol. 1989 Apr;96(4):986-92. doi: 10.1111/j.1476-5381.1989.tb11911.x.
Br J Pharmacol. 1989.
PMID: 2568146
Free PMC article.
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High-throughput screening of RNA polymerase inhibitors using a fluorescent UTP analog.
Bhat J, Rane R, Solapure SM, Sarkar D, Sharma U, Harish MN, Lamb S, Plant D, Alcock P, Peters S, Barde S, Roy RK.
Bhat J, et al.
J Biomol Screen. 2006 Dec;11(8):968-76. doi: 10.1177/1087057106291978. Epub 2006 Oct 4.
J Biomol Screen. 2006.
PMID: 17021309
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