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The MDM2 promoter SNP285C/309G haplotype diminishes Sp1 transcription factor binding and reduces risk for breast and ovarian cancer in Caucasians.
Knappskog S, Bjørnslett M, Myklebust LM, Huijts PE, Vreeswijk MP, Edvardsen H, Guo Y, Zhang X, Yang M, Ylisaukko-Oja SK, Alhopuro P, Arola J, Tollenaar RA, van Asperen CJ, Seynaeve C, Staalesen V, Chrisanthar R, Løkkevik E, Salvesen HB, Evans DG, Newman WG, Lin D, Aaltonen LA, Børresen-Dale AL, Tell GS, Stoltenberg C, Romundstad P, Hveem K, Lillehaug JR, Vatten L, Devilee P, Dørum A, Lønning PE. Knappskog S, et al. Among authors: alhopuro p. Cancer Cell. 2011 Feb 15;19(2):273-82. doi: 10.1016/j.ccr.2010.12.019. Cancer Cell. 2011. PMID: 21316605 Free article.
The MDM2 promoter polymorphism SNP309T-->G and the risk of uterine leiomyosarcoma, colorectal cancer, and squamous cell carcinoma of the head and neck.
Alhopuro P, Ylisaukko-Oja SK, Koskinen WJ, Bono P, Arola J, Järvinen HJ, Mecklin JP, Atula T, Kontio R, Mäkitie AA, Suominen S, Leivo I, Vahteristo P, Aaltonen LM, Aaltonen LA. Alhopuro P, et al. J Med Genet. 2005 Sep;42(9):694-8. doi: 10.1136/jmg.2005.031260. J Med Genet. 2005. PMID: 16141004 Free PMC article.
MDM2 SNP309 accelerates colorectal tumour formation in women.
Bond GL, Menin C, Bertorelle R, Alhopuro P, Aaltonen LA, Levine AJ. Bond GL, et al. Among authors: alhopuro p. J Med Genet. 2006 Dec;43(12):950-2. doi: 10.1136/jmg.2006.043539. Epub 2006 Jul 6. J Med Genet. 2006. PMID: 16825430 Free PMC article.
Tumour selection advantage of non-dominant negative P53 mutations in homozygotic MDM2-SNP309 colorectal cancer cells.
Alazzouzi H, Suriano G, Guerra A, Plaja A, Espín E, Armengol M, Alhopuro P, Velho S, Shinomura Y, González-Aguilera JJ, Yamamoto H, Aaltonen LA, Moreno V, Capellà G, Peinado MA, Seruca R, Arango D, Schwartz S Jr. Alazzouzi H, et al. Among authors: alhopuro p. J Med Genet. 2007 Jan;44(1):75-80. doi: 10.1136/jmg.2006.042572. Epub 2006 Jul 6. J Med Genet. 2007. PMID: 16825434 Free PMC article.
Mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADalpha, and MO25alpha, in Peutz-Jeghers syndrome.
Alhopuro P, Katajisto P, Lehtonen R, Ylisaukko-Oja SK, Näätsaari L, Karhu A, Westerman AM, Wilson JH, de Rooij FW, Vogel T, Moeslein G, Tomlinson IP, Aaltonen LA, Mäkelä TP, Launonen V. Alhopuro P, et al. Br J Cancer. 2005 Mar 28;92(6):1126-9. doi: 10.1038/sj.bjc.6602454. Br J Cancer. 2005. PMID: 15756273 Free PMC article.
Background mutation frequency in microsatellite-unstable colorectal cancer.
Sammalkorpi H, Alhopuro P, Lehtonen R, Tuimala J, Mecklin JP, Järvinen HJ, Jiricny J, Karhu A, Aaltonen LA. Sammalkorpi H, et al. Among authors: alhopuro p. Cancer Res. 2007 Jun 15;67(12):5691-8. doi: 10.1158/0008-5472.CAN-06-4314. Cancer Res. 2007. PMID: 17575135
29 results