Alvaro R - Search Results

1

Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain.

Chobanian HR, Guo Y, Liu P, Chioda MD, Fung S, Lanza TJ, Chang L, Bakshi RK, Dellureficio JP, Hong Q, McLaughlin M, Belyk KM, Krska SW, Makarewicz AK, Martel EJ, Leone JF, Frey L, Karanam B, Madeira M, Alvaro R, Shuman J, Salituro G, Terebetski JL, Jochnowitz N, Mistry S, McGowan E, Hajdu R, Rosenbach M, Abbadie C, Alexander JP, Shiao LL, Sullivan KM, Nargund RP, Wyvratt MJ, Lin LS, DeVita RJ. Chobanian HR, et al. Among authors: alvaro r. ACS Med Chem Lett. 2014 Apr 10;5(6):717-21. doi: 10.1021/ml5001239. eCollection 2014 Jun 12. ACS Med Chem Lett. 2014. PMID: 24944750 Free PMC article.

2

Effects of the immunosuppressant FK-506 and its analog FK-520 on hepatic and renal cytochrome P450 mixed-function oxidase.

Vincent SH, Wang RW, Karanam BV, Klimko M, Alvaro R, Chiu SH. Vincent SH, et al. Among authors: alvaro r. Biochem Pharmacol. 1991 May 1;41(9):1325-30. doi: 10.1016/0006-2952(91)90104-d. Biochem Pharmacol. 1991. PMID: 1708254

3

Novel 2,3-dihydrobenzofuran-2-carboxylic acids: highly potent and subtype-selective PPARalpha agonists with potent hypolipidemic activity.

Shi GQ, Dropinski JF, Zhang Y, Santini C, Sahoo SP, Berger JP, Macnaul KL, Zhou G, Agrawal A, Alvaro R, Cai TQ, Hernandez M, Wright SD, Moller DE, Heck JV, Meinke PT. Shi GQ, et al. Among authors: alvaro r. J Med Chem. 2005 Aug 25;48(17):5589-99. doi: 10.1021/jm050373g. J Med Chem. 2005. PMID: 16107159

4

3-Pyridyloxypropanolamine agonists of the beta 3 adrenergic receptor with improved pharmacokinetic properties.

Weber AE, Ok HO, Alvaro RF, Candelore MR, Cascieri MA, Chiu SH, Deng L, Forrest MJ, Hom GJ, Hutchins JE, Kao J, MacIntyre DE, Mathvink RJ, McLoughlin D, Miller RR, Newbold RC, Olah TV, Parmee ER, Perkins L, Stearns RA, Strader CD, Szumiloski J, Tang YS, Tota L, Fisher MH, et al. Weber AE, et al. Among authors: alvaro rf. Bioorg Med Chem Lett. 1998 Aug 18;8(16):2111-6. doi: 10.1016/s0960-894x(98)00381-3. Bioorg Med Chem Lett. 1998. PMID: 9873496

5

The metabolic activation of ronidazole [(1-methyl-5-nitroimidazole-2-yl)-methyl carbamate] to reactive metabolites by mammalian, cecal bacterial and T. foetus enzymes.

Miwa GT, Wang R, Alvaro R, Walsh JS, Lu AY. Miwa GT, et al. Among authors: alvaro r. Biochem Pharmacol. 1986 Jan 1;35(1):33-6. doi: 10.1016/0006-2952(86)90551-4. Biochem Pharmacol. 1986. PMID: 3940524 No abstract available.

6

Disposition of ivermectin and cyclosporin A in CF-1 mice deficient in mdr1a P-glycoprotein.

Kwei GY, Alvaro RF, Chen Q, Jenkins HJ, Hop CE, Keohane CA, Ly VT, Strauss JR, Wang RW, Wang Z, Pippert TR, Umbenhauer DR. Kwei GY, et al. Among authors: alvaro rf. Drug Metab Dispos. 1999 May;27(5):581-7. Drug Metab Dispos. 1999. PMID: 10220486

7

Drug residue formation from ronidazole, a 5-nitroimidazole. VII. Comparison of protein-bound products formed in vitro and in vivo.

Miwa GT, Alvaro RF, Walsh JS, Wang R, Lu AY. Miwa GT, et al. Among authors: alvaro rf. Chem Biol Interact. 1984 Jul;50(2):189-202. doi: 10.1016/0009-2797(84)90095-4. Chem Biol Interact. 1984. PMID: 6744464

8

Pharmacokinetics and disposition of the oxytocin receptor antagonist L-368,899 in rats and dogs.

Thompson KL, Vincent SH, Miller RR, Colletti AE, Alvaro RF, Wallace MA, Feeney WP, Chiu SH. Thompson KL, et al. Among authors: alvaro rf. Drug Metab Dispos. 1997 Oct;25(10):1113-8. Drug Metab Dispos. 1997. PMID: 9321512

9

Determination of enantiomeric concentrations of a 2,5-diaryltetrahydrofuran (L-668,750), a platelet-activating factor receptor antagonist, in rat plasma using a chiral alpha 1-acid glycoprotein high-performance liquid chromatographic column.

Alvaro RF, Rosegay A, Chiu SH. Alvaro RF, et al. J Chromatogr. 1992 Jul 24;578(2):327-32. doi: 10.1016/0378-4347(92)80434-r. J Chromatogr. 1992. PMID: 1328270

10

The role of drug metabolism in drug discovery: a case study in the selection of an oxytocin receptor antagonist for development.

Chiu SH, Thompson KA, Vincent SH, Alvaro RF, Huskey SW, Stearns RA, Pettibone DJ. Chiu SH, et al. Among authors: alvaro rf. Toxicol Pathol. 1995 Mar-Apr;23(2):124-30. doi: 10.1177/019262339502300204. Toxicol Pathol. 1995. PMID: 7569665 Review.

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