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Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients.
Yuda J, Will C, Phillips DC, Abraham L, Alvey C, Avigdor A, Buck W, Besenhofer L, Boghaert E, Cheng D, Cojocari D, Doyle K, Hansen TM, Huang K, Johnson EF, Judd AS, Judge RA, Kalvass JC, Kunzer A, Lam LT, Li R, Martin RL, Mastracchio A, Mitten M, Petrich A, Wang J, Ward JE, Zhang H, Wang X, Wolff JE, Bell-McGuinn KM, Souers AJ. Yuda J, et al. Among authors: alvey c. Commun Med (Lond). 2023 Oct 25;3(1):154. doi: 10.1038/s43856-023-00380-z. Commun Med (Lond). 2023. PMID: 37880389 Free PMC article.
Synergistic therapeutic benefit by combining the antibody drug conjugate, depatux-m with temozolomide in pre-clinical models of glioblastoma with overexpression of EGFR.
Vaidya KS, Mitten MJ, Zelaya-Lazo AL, Oleksijew A, Alvey C, Falls HD, Mishra S, Palma J, Ansell P, Phillips AC, Reilly EB, Anderson M, Boghaert ER. Vaidya KS, et al. Among authors: alvey c. J Neurooncol. 2021 Apr;152(2):233-243. doi: 10.1007/s11060-021-03703-z. Epub 2021 Jan 30. J Neurooncol. 2021. PMID: 33517558
Development and validation of a Level A in-vitro in-vivo correlation for tofacitinib modified-release tablets using extrudable core system osmotic delivery technology.
Kushner J 4th, Lamba M, Stock T, Wang R, Nemeth MA, Alvey C, Chen R, DeMatteo V, Blanchard A. Kushner J 4th, et al. Among authors: alvey c. Eur J Pharm Sci. 2020 Apr 30;147:105200. doi: 10.1016/j.ejps.2019.105200. Epub 2019 Dec 19. Eur J Pharm Sci. 2020. PMID: 31863865 Free article. Clinical Trial.
Nuclear rupture at sites of high curvature compromises retention of DNA repair factors.
Xia Y, Ivanovska IL, Zhu K, Smith L, Irianto J, Pfeifer CR, Alvey CM, Ji J, Liu D, Cho S, Bennett RR, Liu AJ, Greenberg RA, Discher DE. Xia Y, et al. Among authors: alvey cm. J Cell Biol. 2018 Nov 5;217(11):3796-3808. doi: 10.1083/jcb.201711161. Epub 2018 Aug 31. J Cell Biol. 2018. PMID: 30171044 Free PMC article.
Assessment of the Drug Interaction Potential of Ertugliflozin With Sitagliptin, Metformin, Glimepiride, or Simvastatin in Healthy Subjects.
Dawra VK, Cutler DL, Zhou S, Krishna R, Shi H, Liang Y, Alvey C, Hickman A, Saur D, Terra SG, Sahasrabudhe V. Dawra VK, et al. Among authors: alvey c. Clin Pharmacol Drug Dev. 2019 Apr;8(3):314-325. doi: 10.1002/cpdd.472. Epub 2018 May 22. Clin Pharmacol Drug Dev. 2019. PMID: 29786959 Free PMC article. Clinical Trial.
64 results