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2020 | 1 |
2022 | 1 |
2024 | 0 |
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Sex differences in the genetic architecture of cognitive resilience to Alzheimer's disease.
Brain. 2022 Jul 29;145(7):2541-2554. doi: 10.1093/brain/awac177.
Brain. 2022.
PMID: 35552371
Free PMC article.
Approximately 30% of elderly adults are cognitively unimpaired at time of death despite the presence of Alzheimer's disease neuropathology at autopsy. Studying individuals who are resilient to the cognitive consequences of Alzheimer's disease …
Approximately 30% of elderly adults are cognitively unimpaired at time of death despite the presence of Alzheimer's disease …
Genetic variants and functional pathways associated with resilience to Alzheimer's disease.
Dumitrescu L, Mahoney ER, Mukherjee S, Lee ML, Bush WS, Engelman CD, Lu Q, Fardo DW, Trittschuh EH, Mez J, Kaczorowski C, Hernandez Saucedo H, Widaman KF, Buckley R, Properzi M, Mormino E, Yang HS, Harrison T, Hedden T, Nho K, Andrews SJ, Tommet D, Hadad N, Sanders RE, Ruderfer DM, Gifford KA, Moore AM, Cambronero F, Zhong X, Raghavan NS, Vardarajan B; Alzheimer’s Disease Neuroimaging Initiative (ADNI); Alzheimer’s Disease Genetics Consortium (ADGC), A4 Study Team; Pericak-Vance MA, Farrer LA, Wang LS, Cruchaga C, Schellenberg G, Cox NJ, Haines JL, Keene CD, Saykin AJ, Larson EB, Sperling RA, Mayeux R, Bennett DA, Schneider JA, Crane PK, Jefferson AL, Hohman TJ.
Dumitrescu L, et al.
Brain. 2020 Aug 1;143(8):2561-2575. doi: 10.1093/brain/awaa209.
Brain. 2020.
PMID: 32844198
Free PMC article.
Data were harmonized across 5108 participants from a clinical trial of Alzheimer's disease and three longitudinal cohort studies of cognitive ageing. ...Notably, neither resilience metric was genetically correlated with clinical Alzheimer's …
Data were harmonized across 5108 participants from a clinical trial of Alzheimer's disease and three longitudinal cohor …
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