Appell ML - Search Results

1

Pharmacogenetically based dosing of thiopurines in childhood acute lymphoblastic leukemia: influence on cure rates and risk of second cancer.

Levinsen M, Rotevatn EØ, Rosthøj S, Nersting J, Abrahamsson J, Appell ML, Bergan S, Bechensteen AG, Harila-Saari A, Heyman M, Jonsson OG, Maxild JB, Niemi M, Söderhäll S, Schmiegelow K; Nordic Society of Paediatric Haematology, Oncology. Levinsen M, et al. Among authors: appell ml. Pediatr Blood Cancer. 2014 May;61(5):797-802. doi: 10.1002/pbc.24921. Epub 2014 Jan 3. Pediatr Blood Cancer. 2014. PMID: 24395436

2

No association between relapse hazard and thiopurine methyltransferase geno- or phenotypes in non-high risk acute lymphoblastic leukemia: a NOPHO ALL2008 sub-study.

Nielsen SN, Toksvang LN, Grell K, Nersting J, Abrahamsson J, Lund B, Kanerva J, Jónsson ÓG, Vaitkeviciene G, Pruunsild K, Appell ML, Hjalgrim LL, Schmiegelow K. Nielsen SN, et al. Among authors: appell ml. Cancer Chemother Pharmacol. 2021 Aug;88(2):271-279. doi: 10.1007/s00280-021-04281-7. Epub 2021 Apr 29. Cancer Chemother Pharmacol. 2021. PMID: 33928426

3

Role of TPMT and ITPA variants in mercaptopurine disposition.

Gerbek T, Ebbesen M, Nersting J, Frandsen TL, Appell ML, Schmiegelow K. Gerbek T, et al. Among authors: appell ml. Cancer Chemother Pharmacol. 2018 Mar;81(3):579-586. doi: 10.1007/s00280-018-3525-8. Epub 2018 Feb 1. Cancer Chemother Pharmacol. 2018. PMID: 29387964

4

Methotrexate binds to recombinant thiopurine S-methyltransferase and inhibits enzyme activity after high-dose infusions in childhood leukaemia.

Wennerstrand P, Mårtensson LG, Söderhäll S, Zimdahl A, Appell ML. Wennerstrand P, et al. Among authors: appell ml. Eur J Clin Pharmacol. 2013 Sep;69(9):1641-9. doi: 10.1007/s00228-013-1521-9. Epub 2013 May 10. Eur J Clin Pharmacol. 2013. PMID: 23660772 Clinical Trial.

5

The Role of TPMT, ITPA, and NUDT15 Variants during Mercaptopurine Treatment of Swedish Pediatric Patients with Acute Lymphoblastic Leukemia.

Wahlund M, Nilsson A, Kahlin AZ, Broliden K, Myrberg IH, Appell ML, Berggren A. Wahlund M, et al. Among authors: appell ml. J Pediatr. 2020 Jan;216:150-157.e1. doi: 10.1016/j.jpeds.2019.09.024. Epub 2019 Oct 18. J Pediatr. 2020. PMID: 31635813

6

Characterization of a novel sequence variant, TPMT*28, in the human thiopurine methyltransferase gene.

Appell ML, Wennerstrand P, Peterson C, Hertervig E, Mårtensson LG. Appell ML, et al. Pharmacogenet Genomics. 2010 Nov;20(11):700-7. doi: 10.1097/FPC.0b013e3283402ee4. Pharmacogenet Genomics. 2010. PMID: 20881512

7

Structural characteristics determine the cause of the low enzyme activity of two thiopurine S-methyltransferase allelic variants: a biophysical characterization of TPMT*2 and TPMT*5.

Wennerstrand P, Dametto P, Hennig J, Klingstedt T, Skoglund K, Appell ML, Mårtensson LG. Wennerstrand P, et al. Among authors: appell ml. Biochemistry. 2012 Jul 31;51(30):5912-20. doi: 10.1021/bi300377d. Epub 2012 Jul 16. Biochemistry. 2012. PMID: 22747506

8

Pharmacogenetic studies of thiopurine methyltransferase genotype-phenotype concordance and effect of methotrexate on thiopurine metabolism.

Zimdahl Kahlin A, Helander S, Wennerstrand P, Vikingsson S, Mårtensson LG, Appell ML. Zimdahl Kahlin A, et al. Among authors: appell ml. Basic Clin Pharmacol Toxicol. 2021 Jan;128(1):52-65. doi: 10.1111/bcpt.13483. Epub 2020 Sep 14. Basic Clin Pharmacol Toxicol. 2021. PMID: 32865889 Free PMC article. Review.

9

Comprehensive study of thiopurine methyltransferase genotype, phenotype, and genotype-phenotype discrepancies in Sweden.

Zimdahl Kahlin A, Helander S, Skoglund K, Söderkvist P, Mårtensson LG, Appell ML. Zimdahl Kahlin A, et al. Among authors: appell ml. Biochem Pharmacol. 2019 Jun;164:263-272. doi: 10.1016/j.bcp.2019.04.020. Epub 2019 Apr 18. Biochem Pharmacol. 2019. PMID: 31005613 Free article.

10

One amino acid makes a difference-Characterization of a new TPMT allele and the influence of SAM on TPMT stability.

Iu YPH, Helander S, Kahlin AZ, Cheng CW, Shek CC, Leung MH, Wallner B, Mårtensson LG, Appell ML. Iu YPH, et al. Among authors: appell ml. Sci Rep. 2017 May 2;7:46428. doi: 10.1038/srep46428. Sci Rep. 2017. PMID: 28462921 Free PMC article.

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