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Overcoming interference with the detection of a stable isotopically labeled microtracer in the evaluation of beclabuvir absolute bioavailability using a concomitant microtracer approach.
Jiang H, Titsch C, Zeng J, Jones B, Joyce P, Gandhi Y, Turley W, Burrell R, Aubry AF, Arnold ME. Jiang H, et al. Among authors: arnold me. J Pharm Biomed Anal. 2017 Sep 5;143:9-16. doi: 10.1016/j.jpba.2017.04.030. Epub 2017 May 17. J Pharm Biomed Anal. 2017. PMID: 28544885
Practical and efficient strategy for evaluating oral absolute bioavailability with an intravenous microdose of a stable isotopically-labeled drug using a selected reaction monitoring mass spectrometry assay.
Jiang H, Zeng J, Li W, Bifano M, Gu H, Titsch C, Easter J, Burrell R, Kandoussi H, Aubry AF, Arnold ME. Jiang H, et al. Among authors: arnold me. Anal Chem. 2012 Nov 20;84(22):10031-7. doi: 10.1021/ac3024558. Epub 2012 Nov 6. Anal Chem. 2012. PMID: 23106420
Sensitive and accurate liquid chromatography-tandem mass spectrometry methods for quantitative determination of a novel hepatitis C NS5B inhibitor BMS-791325 and its active metabolite in human plasma and urine.
Jiang H, Demers R, Kandoussi H, Burrell R, Eley T, Kadiyala P, Cojocaru L, Baker C, Ryan J, Aubry AF, Arnold ME, Zeng J. Jiang H, et al. Among authors: arnold me. J Pharm Biomed Anal. 2015 Mar 25;107:17-23. doi: 10.1016/j.jpba.2014.12.011. Epub 2014 Dec 17. J Pharm Biomed Anal. 2015. PMID: 25562845
Multiplexed LC-MS/MS method for the simultaneous quantitation of three novel hepatitis C antivirals, daclatasvir, asunaprevir, and beclabuvir in human plasma.
Jiang H, Kandoussi H, Zeng J, Wang J, Demers R, Eley T, He B, Burrell R, Easter J, Kadiyala P, Pursley J, Cojocaru L, Baker C, Ryan J, Aubry AF, Arnold ME. Jiang H, et al. Among authors: arnold me. J Pharm Biomed Anal. 2015 Mar 25;107:409-18. doi: 10.1016/j.jpba.2015.01.027. Epub 2015 Jan 20. J Pharm Biomed Anal. 2015. PMID: 25676854
A highly sensitive and selective LC-MS/MS method to quantify asunaprevir, an HCV NS3 protease inhibitor, in human plasma in support of pharmacokinetic studies.
Kandoussi H, Jiang H, Zeng J, Zheng N, Kadiyala P, Eley T, He B, Garimella T, Demers R, Cojocaru L, Aubry AF, Arnold ME. Kandoussi H, et al. Among authors: arnold me. J Pharm Biomed Anal. 2016 Feb 5;119:145-51. doi: 10.1016/j.jpba.2015.11.028. Epub 2015 Nov 23. J Pharm Biomed Anal. 2016. PMID: 26683987
175 results