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Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes.
Sims EK, Bahnson HT, Nyalwidhe J, Haataja L, Davis AK, Speake C, DiMeglio LA, Blum J, Morris MA, Mirmira RG, Nadler J, Mastracci TL, Marcovina S, Qian WJ, Yi L, Swensen AC, Yip-Schneider M, Schmidt CM, Considine RV, Arvan P, Greenbaum CJ, Evans-Molina C; T1D Exchange Residual C-peptide Study Group. Sims EK, et al. Among authors: arvan p. Diabetes Care. 2019 Feb;42(2):258-264. doi: 10.2337/dc17-2625. Epub 2018 Dec 10. Diabetes Care. 2019. PMID: 30530850 Free PMC article.
Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants.
Nicolson TJ, Bellomo EA, Wijesekara N, Loder MK, Baldwin JM, Gyulkhandanyan AV, Koshkin V, Tarasov AI, Carzaniga R, Kronenberger K, Taneja TK, da Silva Xavier G, Libert S, Froguel P, Scharfmann R, Stetsyuk V, Ravassard P, Parker H, Gribble FM, Reimann F, Sladek R, Hughes SJ, Johnson PR, Masseboeuf M, Burcelin R, Baldwin SA, Liu M, Lara-Lemus R, Arvan P, Schuit FC, Wheeler MB, Chimienti F, Rutter GA. Nicolson TJ, et al. Among authors: arvan p. Diabetes. 2009 Sep;58(9):2070-83. doi: 10.2337/db09-0551. Epub 2009 Jun 19. Diabetes. 2009. PMID: 19542200 Free PMC article.
Misfolded proinsulin affects bystander proinsulin in neonatal diabetes.
Hodish I, Liu M, Rajpal G, Larkin D, Holz RW, Adams A, Liu L, Arvan P. Hodish I, et al. Among authors: arvan p. J Biol Chem. 2010 Jan 1;285(1):685-94. doi: 10.1074/jbc.M109.038042. Epub 2009 Oct 30. J Biol Chem. 2010. PMID: 19880509 Free PMC article.
It has previously been shown that misfolded mutant Akita proinsulin in the endoplasmic reticulum engages directly in protein complexes either with nonmutant proinsulin or with "hProCpepGFP" (human proinsulin bearing emerald-GFP within the C-peptide), impairing the trafficking of …
It has previously been shown that misfolded mutant Akita proinsulin in the endoplasmic reticulum engages directly in protein complexes eithe …
Proinsulin misfolding and diabetes: mutant INS gene-induced diabetes of youth.
Liu M, Hodish I, Haataja L, Lara-Lemus R, Rajpal G, Wright J, Arvan P. Liu M, et al. Among authors: arvan p. Trends Endocrinol Metab. 2010 Nov;21(11):652-9. doi: 10.1016/j.tem.2010.07.001. Epub 2010 Aug 18. Trends Endocrinol Metab. 2010. PMID: 20724178 Free PMC article. Review.
In vivo misfolding of proinsulin below the threshold of frank diabetes.
Hodish I, Absood A, Liu L, Liu M, Haataja L, Larkin D, Al-Khafaji A, Zaki A, Arvan P. Hodish I, et al. Among authors: arvan p. Diabetes. 2011 Aug;60(8):2092-101. doi: 10.2337/db10-1671. Epub 2011 Jun 15. Diabetes. 2011. PMID: 21677281 Free PMC article.
210 results