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Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein response, and disturbance in the expression of metabolic enzymes but not with insulin resistance.
Meakin PJ, Chowdhry S, Sharma RS, Ashford FB, Walsh SV, McCrimmon RJ, Dinkova-Kostova AT, Dillon JF, Hayes JD, Ashford ML. Meakin PJ, et al. Among authors: ashford fb. Mol Cell Biol. 2014 Sep;34(17):3305-20. doi: 10.1128/MCB.00677-14. Epub 2014 Jun 23. Mol Cell Biol. 2014. PMID: 24958099 Free PMC article.
Vitamin-D-Binding Protein Contributes to the Maintenance of α Cell Function and Glucagon Secretion.
Viloria K, Nasteska D, Briant LJB, Heising S, Larner DP, Fine NHF, Ashford FB, da Silva Xavier G, Ramos MJ, Hasib A, Cuozzo F, Manning Fox JE, MacDonald PE, Akerman I, Lavery GG, Flaxman C, Morgan NG, Richardson SJ, Hewison M, Hodson DJ. Viloria K, et al. Among authors: ashford fb. Cell Rep. 2020 Jun 16;31(11):107761. doi: 10.1016/j.celrep.2020.107761. Cell Rep. 2020. PMID: 32553153 Free PMC article.
Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics.
Ast J, Arvaniti A, Fine NHF, Nasteska D, Ashford FB, Stamataki Z, Koszegi Z, Bacon A, Jones BJ, Lucey MA, Sasaki S, Brierley DI, Hastoy B, Tomas A, D'Agostino G, Reimann F, Lynn FC, Reissaus CA, Linnemann AK, D'Este E, Calebiro D, Trapp S, Johnsson K, Podewin T, Broichhagen J, Hodson DJ. Ast J, et al. Among authors: ashford fb. Nat Commun. 2020 Jan 24;11(1):467. doi: 10.1038/s41467-020-14309-w. Nat Commun. 2020. PMID: 31980626 Free PMC article.
Author Correction: Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics.
Ast J, Arvaniti A, Fine NHF, Nasteska D, Ashford FB, Stamataki Z, Koszegi Z, Bacon A, Jones BJ, Lucey MA, Sasaki S, Brierley DI, Hastoy B, Tomas A, D'Agostino G, Reimann F, Lynn FC, Reissaus CA, Linnemann AK, D'Este E, Calebiro D, Trapp S, Johnsson K, Podewin T, Broichhagen J, Hodson DJ. Ast J, et al. Among authors: ashford fb. Nat Commun. 2020 Oct 9;11(1):5160. doi: 10.1038/s41467-020-19101-4. Nat Commun. 2020. PMID: 33037231 Free PMC article.
PDX1LOW MAFALOW β-cells contribute to islet function and insulin release.
Nasteska D, Fine NHF, Ashford FB, Cuozzo F, Viloria K, Smith G, Dahir A, Dawson PWJ, Lai YC, Bastidas-Ponce A, Bakhti M, Rutter GA, Fiancette R, Nano R, Piemonti L, Lickert H, Zhou Q, Akerman I, Hodson DJ. Nasteska D, et al. Among authors: ashford fb. Nat Commun. 2021 Jan 29;12(1):674. doi: 10.1038/s41467-020-20632-z. Nat Commun. 2021. PMID: 33514698 Free PMC article.
Partial agonism improves the anti-hyperglycaemic efficacy of an oxyntomodulin-derived GLP-1R/GCGR co-agonist.
Pickford P, Lucey M, Rujan RM, McGlone ER, Bitsi S, Ashford FB, Corrêa IR, Hodson DJ, Tomas A, Deganutti G, Reynolds CA, Owen BM, Tan TM, Minnion J, Jones B, Bloom SR. Pickford P, et al. Among authors: ashford fb. Mol Metab. 2021 Sep;51:101242. doi: 10.1016/j.molmet.2021.101242. Epub 2021 Apr 30. Mol Metab. 2021. PMID: 33933675 Free PMC article.
Author Correction: PDX1LOW MAFALOW β-cells contribute to islet function and insulin release.
Nasteska D, Fine NHF, Ashford FB, Cuozzo F, Viloria K, Smith G, Dahir A, Dawson PWJ, Lai YC, Bastidas-Ponce A, Bakhti M, Rutter GA, Fiancette R, Nano R, Piemonti L, Lickert H, Zhou Q, Akerman I, Hodson DJ. Nasteska D, et al. Among authors: ashford fb. Nat Commun. 2021 Jul 20;12(1):4521. doi: 10.1038/s41467-021-24848-5. Nat Commun. 2021. PMID: 34285239 Free PMC article. No abstract available.
27 results