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Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein response, and disturbance in the expression of metabolic enzymes but not with insulin resistance.
Meakin PJ, Chowdhry S, Sharma RS, Ashford FB, Walsh SV, McCrimmon RJ, Dinkova-Kostova AT, Dillon JF, Hayes JD, Ashford ML. Meakin PJ, et al. Among authors: ashford ml, ashford fb. Mol Cell Biol. 2014 Sep;34(17):3305-20. doi: 10.1128/MCB.00677-14. Epub 2014 Jun 23. Mol Cell Biol. 2014. PMID: 24958099 Free PMC article.
145 results