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The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury.
Sandanger Ø, Ranheim T, Vinge LE, Bliksøen M, Alfsnes K, Finsen AV, Dahl CP, Askevold ET, Florholmen G, Christensen G, Fitzgerald KA, Lien E, Valen G, Espevik T, Aukrust P, Yndestad A. Sandanger Ø, et al. Among authors: askevold et. Cardiovasc Res. 2013 Jul 1;99(1):164-74. doi: 10.1093/cvr/cvt091. Epub 2013 Apr 10. Cardiovasc Res. 2013. PMID: 23580606
Interleukin 27 is increased in carotid atherosclerosis and promotes NLRP3 inflammasome activation.
Gregersen I, Sandanger Ø, Askevold ET, Sagen EL, Yang K, Holm S, Pedersen TM, Skjelland M, Krohg-Sørensen K, Hansen TV, Dahl TB, Otterdal K, Espevik T, Aukrust P, Yndestad A, Halvorsen B. Gregersen I, et al. Among authors: askevold et. PLoS One. 2017 Nov 27;12(11):e0188387. doi: 10.1371/journal.pone.0188387. eCollection 2017. PLoS One. 2017. PMID: 29176764 Free PMC article.
Innate immune signaling induces expression and shedding of the heparan sulfate proteoglycan syndecan-4 in cardiac fibroblasts and myocytes, affecting inflammation in the pressure-overloaded heart.
Strand ME, Herum KM, Rana ZA, Skrbic B, Askevold ET, Dahl CP, Vistnes M, Hasic A, Kvaløy H, Sjaastad I, Carlson CR, Tønnessen T, Gullestad L, Christensen G, Lunde IG. Strand ME, et al. Among authors: askevold et. FEBS J. 2013 May;280(10):2228-47. doi: 10.1111/febs.12161. Epub 2013 Feb 24. FEBS J. 2013. PMID: 23374111 Free article.
Lumican is increased in experimental and clinical heart failure, and its production by cardiac fibroblasts is induced by mechanical and proinflammatory stimuli.
Engebretsen KV, Lunde IG, Strand ME, Waehre A, Sjaastad I, Marstein HS, Skrbic B, Dahl CP, Askevold ET, Christensen G, Bjørnstad JL, Tønnessen T. Engebretsen KV, et al. Among authors: askevold et. FEBS J. 2013 May;280(10):2382-98. doi: 10.1111/febs.12235. Epub 2013 Apr 2. FEBS J. 2013. PMID: 23480731 Free article.
The homeostatic chemokine CCL21 predicts mortality in aortic stenosis patients and modulates left ventricular remodeling.
Finsen AV, Ueland T, Sjaastad I, Ranheim T, Ahmed MS, Dahl CP, Askevold ET, Aakhus S, Husberg C, Fiane AE, Lipp M, Gullestad L, Christensen G, Aukrust P, Yndestad A. Finsen AV, et al. Among authors: askevold et. PLoS One. 2014 Nov 14;9(11):e112172. doi: 10.1371/journal.pone.0112172. eCollection 2014. PLoS One. 2014. PMID: 25398010 Free PMC article.
Wnt5a is elevated in heart failure and affects cardiac fibroblast function.
Abraityte A, Vinge LE, Askevold ET, Lekva T, Michelsen AE, Ranheim T, Alfsnes K, Fiane A, Aakhus S, Lunde IG, Dahl CP, Aukrust P, Christensen G, Gullestad L, Yndestad A, Ueland T. Abraityte A, et al. Among authors: askevold et. J Mol Med (Berl). 2017 Jul;95(7):767-777. doi: 10.1007/s00109-017-1529-1. Epub 2017 Mar 30. J Mol Med (Berl). 2017. PMID: 28357477
The cardiokine secreted Frizzled-related protein 3, a modulator of Wnt signalling, in clinical and experimental heart failure.
Askevold ET, Aukrust P, Nymo SH, Lunde IG, Kaasbøll OJ, Aakhus S, Florholmen G, Ohm IK, Strand ME, Attramadal H, Fiane A, Dahl CP, Finsen AV, Vinge LE, Christensen G, Yndestad A, Gullestad L, Latini R, Masson S, Tavazzi L; GISSI-HF Investigators; Ueland T. Askevold ET, et al. J Intern Med. 2014 Jun;275(6):621-30. doi: 10.1111/joim.12175. Epub 2014 Jan 9. J Intern Med. 2014. PMID: 24330105 Free article.
Circulating nucleosomes in chronic heart failure.
Nymo SH, Ueland T, Askevold E, Dahl CP, Gullestad L, Aukrust P, Yndestad A. Nymo SH, et al. Int J Cardiol. 2016 Jan 15;203:742-3. doi: 10.1016/j.ijcard.2015.10.219. Epub 2015 Oct 28. Int J Cardiol. 2016. PMID: 26595779 No abstract available.
27 results