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Innate immune signaling induces expression and shedding of the heparan sulfate proteoglycan syndecan-4 in cardiac fibroblasts and myocytes, affecting inflammation in the pressure-overloaded heart.
Strand ME, Herum KM, Rana ZA, Skrbic B, Askevold ET, Dahl CP, Vistnes M, Hasic A, Kvaløy H, Sjaastad I, Carlson CR, Tønnessen T, Gullestad L, Christensen G, Lunde IG. Strand ME, et al. Among authors: askevold et. FEBS J. 2013 May;280(10):2228-47. doi: 10.1111/febs.12161. Epub 2013 Feb 24. FEBS J. 2013. PMID: 23374111 Free article.
Secreted Wnt modulators in symptomatic aortic stenosis.
Askevold ET, Gullestad L, Aakhus S, Ranheim T, Tønnessen T, Solberg OG, Aukrust P, Ueland T. Askevold ET, et al. J Am Heart Assoc. 2012 Dec;1(6):e002261. doi: 10.1161/JAHA.112.002261. Epub 2012 Dec 19. J Am Heart Assoc. 2012. PMID: 23316316 Free PMC article.
Lumican is increased in experimental and clinical heart failure, and its production by cardiac fibroblasts is induced by mechanical and proinflammatory stimuli.
Engebretsen KV, Lunde IG, Strand ME, Waehre A, Sjaastad I, Marstein HS, Skrbic B, Dahl CP, Askevold ET, Christensen G, Bjørnstad JL, Tønnessen T. Engebretsen KV, et al. Among authors: askevold et. FEBS J. 2013 May;280(10):2382-98. doi: 10.1111/febs.12235. Epub 2013 Apr 2. FEBS J. 2013. PMID: 23480731 Free article.
The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury.
Sandanger Ø, Ranheim T, Vinge LE, Bliksøen M, Alfsnes K, Finsen AV, Dahl CP, Askevold ET, Florholmen G, Christensen G, Fitzgerald KA, Lien E, Valen G, Espevik T, Aukrust P, Yndestad A. Sandanger Ø, et al. Among authors: askevold et. Cardiovasc Res. 2013 Jul 1;99(1):164-74. doi: 10.1093/cvr/cvt091. Epub 2013 Apr 10. Cardiovasc Res. 2013. PMID: 23580606
The homeostatic chemokine CCL21 predicts mortality in aortic stenosis patients and modulates left ventricular remodeling.
Finsen AV, Ueland T, Sjaastad I, Ranheim T, Ahmed MS, Dahl CP, Askevold ET, Aakhus S, Husberg C, Fiane AE, Lipp M, Gullestad L, Christensen G, Aukrust P, Yndestad A. Finsen AV, et al. Among authors: askevold et. PLoS One. 2014 Nov 14;9(11):e112172. doi: 10.1371/journal.pone.0112172. eCollection 2014. PLoS One. 2014. PMID: 25398010 Free PMC article.
Soluble glycoprotein 130 predicts fatal outcomes in chronic heart failure: analysis from the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA).
Askevold ET, Nymo S, Ueland T, Gravning J, Wergeland R, Kjekshus J, Yndestad A, Cleland JG, McMurray JJ, Aukrust P, Gullestad L. Askevold ET, et al. Circ Heart Fail. 2013 Jan;6(1):91-8. doi: 10.1161/CIRCHEARTFAILURE.112.972653. Epub 2012 Dec 10. Circ Heart Fail. 2013. PMID: 23230311 Clinical Trial.
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