Astles PC - Search Results

1

Astles PC, Harris NV, Morley AD. Astles PC, et al. Bioorg Med Chem. 2001 Aug;9(8):2195-202. doi: 10.1016/s0968-0896(01)00132-8. Bioorg Med Chem. 2001. PMID: 11504657

2

Acyl-CoA:Cholesterol O-acyltransferase (ACAT) inhibitors. 2. 2-(1,3-Dioxan-2-yl)-4,5-diphenyl-1H-imidazoles as potent inhibitors of ACAT.

Astles PC, Ashton MJ, Bridge AW, Harris NV, Hart TW, Parrott DP, Porter B, Riddell D, Smith C, Williams RJ. Astles PC, et al. J Med Chem. 1996 Mar 29;39(7):1423-32. doi: 10.1021/jm9505876. J Med Chem. 1996. PMID: 8691472

3

Selective endothelin A receptor antagonists. 3. Discovery and structure-activity relationships of a series of 4-phenoxybutanoic acid derivatives.

Astles PC, Brealey C, Brown TJ, Facchini V, Handscombe C, Harris NV, McCarthy C, McLay IM, Porter B, Roach AG, Sargent C, Smith C, Walsh RJ. Astles PC, et al. J Med Chem. 1998 Jul 16;41(15):2732-44. doi: 10.1021/jm9707131. J Med Chem. 1998. PMID: 9667964

4

Selective endothelin A receptor antagonists. 4. Discovery and structure-activity relationships of stilbene acid and alcohol derivatives.

Astles PC, Brown TJ, Halley F, Handscombe CM, Harris NV, McCarthy C, McLay IM, Lockey P, Majid T, Porter B, Roach AG, Smith C, Walsh R. Astles PC, et al. J Med Chem. 1998 Jul 16;41(15):2745-53. doi: 10.1021/jm970847e. J Med Chem. 1998. PMID: 9667965

5

Selective ET(A) antagonists. 5. Discovery and structure-activity relationships of phenoxyphenylacetic acid derivatives.

Astles PC, Brown TJ, Halley F, Handscombe CM, Harris NV, Majid TN, McCarthy C, McLay IM, Morley A, Porter B, Roach AG, Sargent C, Smith C, Walsh RJ. Astles PC, et al. J Med Chem. 2000 Mar 9;43(5):900-10. doi: 10.1021/jm990378b. J Med Chem. 2000. PMID: 10715156

6

Structure based design of 4-(3-aminomethylphenyl)piperidinyl-1-amides: novel, potent, selective, and orally bioavailable inhibitors of betaII tryptase.

Levell J, Astles P, Eastwood P, Cairns J, Houille O, Aldous S, Merriman G, Whiteley B, Pribish J, Czekaj M, Liang G, Maignan S, Guilloteau JP, Dupuy A, Davidson J, Harrison T, Morley A, Watson S, Fenton G, McCarthy C, Romano J, Mathew R, Engers D, Gardyan M, Sides K, Kwong J, Tsay J, Rebello S, Shen L, Wang J, Luo Y, Giardino O, Lim HK, Smith K, Pauls H. Levell J, et al. Bioorg Med Chem. 2005 Apr 15;13(8):2859-72. doi: 10.1016/j.bmc.2005.02.014. Bioorg Med Chem. 2005. PMID: 15781396

7

Selective cannabinoid receptor type 2 (CB2) agonists: optimization of a series of purines leading to the identification of a clinical candidate for the treatment of osteoarthritic pain.

Hollinshead SP, Tidwell MW, Palmer J, Guidetti R, Sanderson A, Johnson MP, Chambers MG, Oskins J, Stratford R, Astles PC. Hollinshead SP, et al. Among authors: astles pc. J Med Chem. 2013 Jul 25;56(14):5722-33. doi: 10.1021/jm400305d. Epub 2013 Jul 3. J Med Chem. 2013. PMID: 23795771

8

The SAR development of substituted purine derivatives as selective CB2 agonists for the treatment of chronic pain.

Guidetti R, Astles PC, Sanderson AJ, Hollinshead SP, Johnson MP, Chambers MG. Guidetti R, et al. Among authors: astles pc. Bioorg Med Chem Lett. 2014 Dec 15;24(24):5572-5575. doi: 10.1016/j.bmcl.2014.11.006. Epub 2014 Nov 7. Bioorg Med Chem Lett. 2014. PMID: 25466177

9

Discovery and optimization of novel purines as potent and selective CB2 agonists.

Hollinshead SP, Astles PC, Chambers MG, Johnson MP, Palmer J, Tidwell MW. Hollinshead SP, et al. Among authors: astles pc. Bioorg Med Chem Lett. 2012 Aug 1;22(15):4962-6. doi: 10.1016/j.bmcl.2012.06.035. Epub 2012 Jun 16. Bioorg Med Chem Lett. 2012. PMID: 22765893

10

Recent progress in the development of subtype selective nicotinic acetylcholine receptor ligands.

Astles PC, Baker SR, Boot JR, Broad LM, Dell CP, Keenan M. Astles PC, et al. Curr Drug Targets CNS Neurol Disord. 2002 Aug;1(4):337-48. doi: 10.2174/1568007023339256. Curr Drug Targets CNS Neurol Disord. 2002. PMID: 12769608 Review.

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