Astudillo L - Search Results

1

Reduction of the internal disulfide bond between Cys 38 and 83 switches the ligand migration pathway in cytoglobin.

Astudillo L, Bernad S, Derrien V, Sebban P, Miksovska J. Astudillo L, et al. J Inorg Biochem. 2013 Dec;129:23-9. doi: 10.1016/j.jinorgbio.2013.08.006. Epub 2013 Aug 16. J Inorg Biochem. 2013. PMID: 24008134

2

Probing the role of the internal disulfide bond in regulating conformational dynamics in neuroglobin.

Astudillo L, Bernad S, Derrien V, Sebban P, Miksovska J. Astudillo L, et al. Biophys J. 2010 Jul 21;99(2):L16-8. doi: 10.1016/j.bpj.2010.04.033. Biophys J. 2010. PMID: 20643048 Free PMC article.

3

Conformational dynamics in human neuroglobin: effect of His64, Val68, and Cys120 on ligand migration.

Astudillo L, Bernad S, Derrien V, Sebban P, Miksovska J. Astudillo L, et al. Biochemistry. 2012 Dec 18;51(50):9984-94. doi: 10.1021/bi301016u. Epub 2012 Dec 5. Biochemistry. 2012. PMID: 23176629

4

Quantitative study of protein-protein interactions by quartz nanopipettes.

Tiwari PB, Astudillo L, Miksovska J, Wang X, Li W, Darici Y, He J. Tiwari PB, et al. Among authors: astudillo l. Nanoscale. 2014 Sep 7;6(17):10255-63. doi: 10.1039/c4nr02964j. Nanoscale. 2014. PMID: 25060094

5

The CK1α Activator Pyrvinium Enhances the Catalytic Efficiency (k_cat/K_m) of CK1α.

Shen C, Li B, Astudillo L, Deutscher MP, Cobb MH, Capobianco AJ, Lee E, Robbins DJ. Shen C, et al. Among authors: astudillo l. Biochemistry. 2019 Dec 24;58(51):5102-5106. doi: 10.1021/acs.biochem.9b00891. Epub 2019 Dec 10. Biochemistry. 2019. PMID: 31820934 Free PMC article.

6

The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis.

Astudillo L, Da Silva TG, Wang Z, Han X, Jin K, VanWye J, Zhu X, Weaver K, Oashi T, Lopes PE, Orton D, Neitzel LR, Lee E, Landgraf R, Robbins DJ, MacKerell AD Jr, Capobianco AJ. Astudillo L, et al. Cancer Res. 2016 Jun 15;76(12):3593-603. doi: 10.1158/0008-5472.CAN-16-0061. Epub 2016 Apr 13. Cancer Res. 2016. PMID: 27197169 Free PMC article.

7

Notch Represses Transcription by PRC2 Recruitment to the Ternary Complex.

Han X, Ranganathan P, Tzimas C, Weaver KL, Jin K, Astudillo L, Zhou W, Zhu X, Li B, Robbins DJ, Capobianco AJ. Han X, et al. Among authors: astudillo l. Mol Cancer Res. 2017 Sep;15(9):1173-1183. doi: 10.1158/1541-7786.MCR-17-0241. Epub 2017 Jun 5. Mol Cancer Res. 2017. PMID: 28584023 Free PMC article.

8

Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors.

Li B, Orton D, Neitzel LR, Astudillo L, Shen C, Long J, Chen X, Kirkbride KC, Doundoulakis T, Guerra ML, Zaias J, Fei DL, Rodriguez-Blanco J, Thorne C, Wang Z, Jin K, Nguyen DM, Sands LR, Marchetti F, Abreu MT, Cobb MH, Capobianco AJ, Lee E, Robbins DJ. Li B, et al. Among authors: astudillo l. Sci Signal. 2017 Jun 27;10(485):eaak9916. doi: 10.1126/scisignal.aak9916. Sci Signal. 2017. PMID: 28655862 Free PMC article.

9

Pharmacological Disruption of the Notch1 Transcriptional Complex Inhibits Tumor Growth by Selectively Targeting Cancer Stem Cells.

Alvarez-Trotta A, Guerrant W, Astudillo L, Lahiry M, Diluvio G, Shersher E, Kaneku H, Robbins DJ, Orton D, Capobianco AJ. Alvarez-Trotta A, et al. Among authors: astudillo l. Cancer Res. 2021 Jun 15;81(12):3347-3357. doi: 10.1158/0008-5472.CAN-20-3611. Epub 2021 Apr 5. Cancer Res. 2021. PMID: 33820800 Free PMC article.

10

A novel chemical attack on Notch-mediated transcription by targeting the NACK ATPase.

Diluvio G, Kelley TT, Lahiry M, Alvarez-Trotta A, Kolb EM, Shersher E, Astudillo L, Kovall RA, Schürer SC, Capobianco AJ. Diluvio G, et al. Among authors: astudillo l. Mol Ther Oncolytics. 2023 Feb 22;28:307-320. doi: 10.1016/j.omto.2023.02.008. eCollection 2023 Mar 16. Mol Ther Oncolytics. 2023. PMID: 36938545 Free PMC article.

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