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Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagy.
Drießen S, Berleth N, Friesen O, Löffler AS, Böhler P, Hieke N, Stuhldreier F, Peter C, Schink KO, Schultz SW, Stenmark H, Holland P, Simonsen A, Wesselborg S, Stork B. Drießen S, et al. Among authors: bohler p. Autophagy. 2015;11(9):1458-70. doi: 10.1080/15548627.2015.1067359. Autophagy. 2015. PMID: 26207339 Free PMC article.
Expression of a ULK1/2 binding-deficient ATG13 variant can partially restore autophagic activity in ATG13-deficient cells.
Hieke N, Löffler AS, Kaizuka T, Berleth N, Böhler P, Drießen S, Stuhldreier F, Friesen O, Assani K, Schmitz K, Peter C, Diedrich B, Dengjel J, Holland P, Simonsen A, Wesselborg S, Mizushima N, Stork B. Hieke N, et al. Among authors: bohler p. Autophagy. 2015;11(9):1471-83. doi: 10.1080/15548627.2015.1068488. Autophagy. 2015. PMID: 26213203 Free PMC article.
Systematic analysis of ATG13 domain requirements for autophagy induction.
Wallot-Hieke N, Verma N, Schlütermann D, Berleth N, Deitersen J, Böhler P, Stuhldreier F, Wu W, Seggewiß S, Peter C, Gohlke H, Mizushima N, Stork B. Wallot-Hieke N, et al. Among authors: bohler p. Autophagy. 2018;14(5):743-763. doi: 10.1080/15548627.2017.1387342. Epub 2018 Mar 21. Autophagy. 2018. PMID: 29173006 Free PMC article.
The Autophagy-Initiating Kinase ULK1 Controls RIPK1-Mediated Cell Death.
Wu W, Wang X, Berleth N, Deitersen J, Wallot-Hieke N, Böhler P, Schlütermann D, Stuhldreier F, Cox J, Schmitz K, Seggewiß S, Peter C, Kasof G, Stefanski A, Stühler K, Tschapek A, Gödecke A, Stork B. Wu W, et al. Among authors: bohler p. Cell Rep. 2020 Apr 21;31(3):107547. doi: 10.1016/j.celrep.2020.107547. Cell Rep. 2020. PMID: 32320653 Free article.
Targeting urothelial carcinoma cells by combining cisplatin with a specific inhibitor of the autophagy-inducing class III PtdIns3K complex.
Schlütermann D, Skowron MA, Berleth N, Böhler P, Deitersen J, Stuhldreier F, Wallot-Hieke N, Wu W, Peter C, Hoffmann MJ, Niegisch G, Stork B. Schlütermann D, et al. Among authors: bohler p. Urol Oncol. 2018 Apr;36(4):160.e1-160.e13. doi: 10.1016/j.urolonc.2017.11.021. Epub 2017 Dec 21. Urol Oncol. 2018. PMID: 29276062 Free article.
PDK1 controls upstream PI3K expression and PIP3 generation.
Dieterle AM, Böhler P, Keppeler H, Alers S, Berleth N, Drießen S, Hieke N, Pietkiewicz S, Löffler AS, Peter C, Gray A, Leslie NR, Shinohara H, Kurosaki T, Engelke M, Wienands J, Bonin M, Wesselborg S, Stork B. Dieterle AM, et al. Among authors: bohler p. Oncogene. 2014 Jun 5;33(23):3043-53. doi: 10.1038/onc.2013.266. Epub 2013 Jul 29. Oncogene. 2014. PMID: 23893244
High-throughput screening for natural compound-based autophagy modulators reveals novel chemotherapeutic mode of action for arzanol.
Deitersen J, Berning L, Stuhldreier F, Ceccacci S, Schlütermann D, Friedrich A, Wu W, Sun Y, Böhler P, Berleth N, Mendiburo MJ, Seggewiß S, Anand R, Reichert AS, Monti MC, Proksch P, Stork B. Deitersen J, et al. Among authors: bohler p. Cell Death Dis. 2021 May 31;12(6):560. doi: 10.1038/s41419-021-03830-5. Cell Death Dis. 2021. PMID: 34059630 Free PMC article.
Phomoxanthone A--From Mangrove Forests to Anticancer Therapy.
Frank M, Niemann H, Böhler P, Stork B, Wesselborg S, Lin W, Proksch P. Frank M, et al. Among authors: bohler p. Curr Med Chem. 2015;22(30):3523-32. doi: 10.2174/0929867322666150716115300. Curr Med Chem. 2015. PMID: 26179997 Review.
The mycotoxin phomoxanthone A disturbs the form and function of the inner mitochondrial membrane.
Böhler P, Stuhldreier F, Anand R, Kondadi AK, Schlütermann D, Berleth N, Deitersen J, Wallot-Hieke N, Wu W, Frank M, Niemann H, Wesbuer E, Barbian A, Luyten T, Parys JB, Weidtkamp-Peters S, Borchardt A, Reichert AS, Peña-Blanco A, García-Sáez AJ, Itskanov S, van der Bliek AM, Proksch P, Wesselborg S, Stork B. Böhler P, et al. Cell Death Dis. 2018 Feb 19;9(3):286. doi: 10.1038/s41419-018-0312-8. Cell Death Dis. 2018. PMID: 29459714 Free PMC article.
43 results