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CD4 + T cells are found within endemic Burkitt lymphoma and modulate Burkitt lymphoma precursor cell viability and expression of pathogenically relevant Epstein-Barr virus genes.
Sidorov S, Fux L, Steiner K, Bounlom S, Traxel S, Azzi T, Berisha A, Berger C, Bernasconi M, Niggli FK, Perner Y, Pather S, Kempf W, Nadal D, Bürgler S. Sidorov S, et al. Among authors: burgler s. Cancer Immunol Immunother. 2022 Jun;71(6):1371-1392. doi: 10.1007/s00262-021-03057-5. Epub 2021 Oct 19. Cancer Immunol Immunother. 2022. PMID: 34668039 Free PMC article.
Epstein-Barr virus and malaria upregulate AID and APOBEC3 enzymes, but only AID seems to play a major mutagenic role in Burkitt lymphoma.
Summerauer AM, Jäggi V, Ogwang R, Traxel S, Colombo L, Amundsen E, Eyer T, Subramanian B, Fehr J, Mantel PY, Idro R, Bürgler S. Summerauer AM, et al. Among authors: burgler s. Eur J Immunol. 2022 Aug;52(8):1273-1284. doi: 10.1002/eji.202249820. Epub 2022 May 12. Eur J Immunol. 2022. PMID: 35503749 Free PMC article.
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