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Interstrand disulfide crosslinking of DNA bases supports a double nucleotide unpairing mechanism for flap endonucleases.
Chem Commun (Camb). 2012 Sep 14;48(71):8895-7. doi: 10.1039/c2cc33400c. Epub 2012 Jul 31.
Chem Commun (Camb). 2012.
PMID: 22850542
Free article.
Brønsted analysis and rate-limiting steps for the T5 flap endonuclease catalyzed hydrolysis of exonucleolytic substrates.
Sengerová B, Tomlinson C, Atack JM, Williams R, Sayers JR, Williams NH, Grasby JA.
Sengerová B, et al.
Biochemistry. 2010 Sep 21;49(37):8085-93. doi: 10.1021/bi100895j.
Biochemistry. 2010.
PMID: 20698567
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The 3'-flap pocket of human flap endonuclease 1 is critical for substrate binding and catalysis.
Finger LD, Blanchard MS, Theimer CA, Sengerová B, Singh P, Chavez V, Liu F, Grasby JA, Shen B.
Finger LD, et al.
J Biol Chem. 2009 Aug 14;284(33):22184-22194. doi: 10.1074/jbc.M109.015065. Epub 2009 Jun 11.
J Biol Chem. 2009.
PMID: 19525235
Free PMC article.
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Three metal ions participate in the reaction catalyzed by T5 flap endonuclease.
Syson K, Tomlinson C, Chapados BR, Sayers JR, Tainer JA, Williams NH, Grasby JA.
Syson K, et al.
J Biol Chem. 2008 Oct 17;283(42):28741-6. doi: 10.1074/jbc.M801264200. Epub 2008 Aug 11.
J Biol Chem. 2008.
PMID: 18697748
Free PMC article.
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