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Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.
Howard DM, Adams MJ, Clarke TK, Hafferty JD, Gibson J, Shirali M, Coleman JRI, Hagenaars SP, Ward J, Wigmore EM, Alloza C, Shen X, Barbu MC, Xu EY, Whalley HC, Marioni RE, Porteous DJ, Davies G, Deary IJ, Hemani G, Berger K, Teismann H, Rawal R, Arolt V, Baune BT, Dannlowski U, Domschke K, Tian C, Hinds DA; 23andMe Research Team; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium; Trzaskowski M, Byrne EM, Ripke S, Smith DJ, Sullivan PF, Wray NR, Breen G, Lewis CM, McIntosh AM. Howard DM, et al. Among authors: barbu mc. Nat Neurosci. 2019 Mar;22(3):343-352. doi: 10.1038/s41593-018-0326-7. Epub 2019 Feb 4. Nat Neurosci. 2019. PMID: 30718901 Free PMC article.
Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways.
Howard DM, Adams MJ, Shirali M, Clarke TK, Marioni RE, Davies G, Coleman JRI, Alloza C, Shen X, Barbu MC, Wigmore EM, Gibson J; 23andMe Research Team; Hagenaars SP, Lewis CM, Ward J, Smith DJ, Sullivan PF, Haley CS, Breen G, Deary IJ, McIntosh AM. Howard DM, et al. Among authors: barbu mc. Nat Commun. 2018 Apr 16;9(1):1470. doi: 10.1038/s41467-018-03819-3. Nat Commun. 2018. PMID: 29662059 Free PMC article.
Addendum: Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways.
Howard DM, Adams MJ, Shirali M, Clarke TK, Marioni RE, Davies G, Coleman JRI, Alloza C, Shen X, Barbu MC, Wigmore EM, Gibson J, Hagenaars SP, Lewis CM, Ward J, Smith DJ, Sullivan PF, Haley CS, Breen G, Deary IJ, McIntosh AM. Howard DM, et al. Among authors: barbu mc. Nat Commun. 2018 Aug 30;9(1):3578. doi: 10.1038/s41467-018-05310-5. Nat Commun. 2018. PMID: 30166530 Free PMC article. No abstract available.
Association of Whole-Genome and NETRIN1 Signaling Pathway-Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank.
Barbu MC, Zeng Y, Shen X, Cox SR, Clarke TK, Gibson J, Adams MJ, Johnstone M, Haley CS, Lawrie SM, Deary IJ; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium; 23andMe Research Team; McIntosh AM, Whalley HC. Barbu MC, et al. Biol Psychiatry Cogn Neurosci Neuroimaging. 2019 Jan;4(1):91-100. doi: 10.1016/j.bpsc.2018.07.006. Epub 2018 Jul 31. Biol Psychiatry Cogn Neurosci Neuroimaging. 2019. PMID: 30197049 Free PMC article.
Reversal of proliferation deficits caused by chromosome 16p13.11 microduplication through targeting NFκB signaling: an integrated study of patient-derived neuronal precursor cells, cerebral organoids and in vivo brain imaging.
Johnstone M, Vasistha NA, Barbu MC, Dando O, Burr K, Christopher E, Glen S, Robert C, Fetit R, Macleod KG, Livesey MR, Clair DS, Blackwood DHR, Millar K, Carragher NO, Hardingham GE, Wyllie DJA, Johnstone EC, Whalley HC, McIntosh AM, Lawrie SM, Chandran S. Johnstone M, et al. Among authors: barbu mc. Mol Psychiatry. 2019 Feb;24(2):294-311. doi: 10.1038/s41380-018-0292-1. Epub 2018 Nov 6. Mol Psychiatry. 2019. PMID: 30401811 Free PMC article.
Associations between vascular risk factors and brain MRI indices in UK Biobank.
Cox SR, Lyall DM, Ritchie SJ, Bastin ME, Harris MA, Buchanan CR, Fawns-Ritchie C, Barbu MC, de Nooij L, Reus LM, Alloza C, Shen X, Neilson E, Alderson HL, Hunter S, Liewald DC, Whalley HC, McIntosh AM, Lawrie SM, Pell JP, Tucker-Drob EM, Wardlaw JM, Gale CR, Deary IJ. Cox SR, et al. Among authors: barbu mc. Eur Heart J. 2019 Jul 21;40(28):2290-2300. doi: 10.1093/eurheartj/ehz100. Eur Heart J. 2019. PMID: 30854560 Free PMC article.
Epigenetic prediction of major depressive disorder.
Barbu MC, Shen X, Walker RM, Howard DM, Evans KL, Whalley HC, Porteous DJ, Morris SW, Deary IJ, Zeng Y, Marioni RE, Clarke TK, McIntosh AM. Barbu MC, et al. Mol Psychiatry. 2021 Sep;26(9):5112-5123. doi: 10.1038/s41380-020-0808-3. Epub 2020 Jun 10. Mol Psychiatry. 2021. PMID: 32523041 Free PMC article.
Structural brain correlates of serum and epigenetic markers of inflammation in major depressive disorder.
Green C, Shen X, Stevenson AJ, Conole ELS, Harris MA, Barbu MC, Hawkins EL, Adams MJ, Hillary RF, Lawrie SM, Evans KL, Walker RM, Morris SW, Porteous DJ, Wardlaw JM, Steele JD, Waiter GD, Sandu AL, Campbell A, Marioni RE, Cox SR, Cavanagh J, McIntosh AM, Whalley HC. Green C, et al. Among authors: barbu mc. Brain Behav Immun. 2021 Feb;92:39-48. doi: 10.1016/j.bbi.2020.11.024. Epub 2020 Nov 19. Brain Behav Immun. 2021. PMID: 33221487 Free PMC article.
45 results