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Novel aroyl guanidine anti-trypanosomal compounds that exert opposing effects on parasite energy metabolism.
Varghese S, Srivastava A, Wong SW, Le T, Pitcher N, Mesnard M, Lallemand C, Rahmani R, Moawad SR, Huang F, He T, Sleebs BE, Barrett MP, Sykes ML, Avery VM, Creek DJ, Baell JB. Varghese S, et al. Among authors: barrett mp. Eur J Med Chem. 2024 Mar 15;268:116162. doi: 10.1016/j.ejmech.2024.116162. Epub 2024 Jan 17. Eur J Med Chem. 2024. PMID: 38394930 Free article.
Anti-parasitic benzoxaboroles are ineffective against Theileria parva in vitro.
Steketee PC, Paxton E, Barrett MP, Pearce MC, Connelley TK, Morrison LJ. Steketee PC, et al. Among authors: barrett mp. Int J Parasitol Drugs Drug Resist. 2023 Dec;23:71-77. doi: 10.1016/j.ijpddr.2023.10.003. Epub 2023 Oct 10. Int J Parasitol Drugs Drug Resist. 2023. PMID: 37866107 Free PMC article.
Alignment of multiple metabolomics LC-MS datasets from disparate diseases to reveal fever-associated metabolites.
Năstase AM, Barrett MP, Cárdenas WB, Cordeiro FB, Zambrano M, Andrade J, Chang J, Regato M, Carrillo E, Botana L, Moreno J, Regnault C, Milne K, Spence PJ, Rowe JA, Rogers S. Năstase AM, et al. Among authors: barrett mp. PLoS Negl Trop Dis. 2023 Jul 24;17(7):e0011133. doi: 10.1371/journal.pntd.0011133. eCollection 2023 Jul. PLoS Negl Trop Dis. 2023. PMID: 37486920 Free PMC article.
Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections.
Rao SPS, Gould MK, Noeske J, Saldivia M, Jumani RS, Ng PS, René O, Chen YL, Kaiser M, Ritchie R, Francisco AF, Johnson N, Patra D, Cheung H, Deniston C, Schenk AD, Cortopassi WA, Schmidt RS, Wiedemar N, Thomas B, Palkar R, Ghafar NA, Manoharan V, Luu C, Gable JE, Wan KF, Myburgh E, Mottram JC, Barnes W, Walker J, Wartchow C, Aziz N, Osborne C, Wagner J, Sarko C, Kelly JM, Manjunatha UH, Mäser P, Jiricek J, Lakshminarayana SB, Barrett MP, Diagana TT. Rao SPS, et al. Among authors: barrett mp. Science. 2023 Jun 30;380(6652):1349-1356. doi: 10.1126/science.adh0614. Epub 2023 Jun 29. Science. 2023. PMID: 37384702 Free article.
The legacy of penicillin's first patient.
Barrett MP. Barrett MP. Pharmacol Res. 2023 Jun;192:106772. doi: 10.1016/j.phrs.2023.106772. Epub 2023 Apr 14. Pharmacol Res. 2023. PMID: 37062418 Free article. No abstract available.
Drug resistance in Leishmania: does it really matter?
Domagalska MA, Barrett MP, Dujardin JC. Domagalska MA, et al. Among authors: barrett mp. Trends Parasitol. 2023 Apr;39(4):251-259. doi: 10.1016/j.pt.2023.01.012. Epub 2023 Feb 17. Trends Parasitol. 2023. PMID: 36803859 Review.
270 results