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A first-in-class, first-in-human, phase I trial of p28, a non-HDM2-mediated peptide inhibitor of p53 ubiquitination in patients with advanced solid tumours.
Warso MA, Richards JM, Mehta D, Christov K, Schaeffer C, Rae Bressler L, Yamada T, Majumdar D, Kennedy SA, Beattie CW, Das Gupta TK. Warso MA, et al. Among authors: beattie cw. Br J Cancer. 2013 Mar 19;108(5):1061-70. doi: 10.1038/bjc.2013.74. Epub 2013 Feb 28. Br J Cancer. 2013. PMID: 23449360 Free PMC article. Clinical Trial.
Noncationic peptides obtained from azurin preferentially enter cancer cells.
Taylor BN, Mehta RR, Yamada T, Lekmine F, Christov K, Chakrabarty AM, Green A, Bratescu L, Shilkaitis A, Beattie CW, Das Gupta TK. Taylor BN, et al. Among authors: beattie cw. Cancer Res. 2009 Jan 15;69(2):537-46. doi: 10.1158/0008-5472.CAN-08-2932. Cancer Res. 2009. PMID: 19147567
p28, a first in class peptide inhibitor of cop1 binding to p53.
Yamada T, Christov K, Shilkaitis A, Bratescu L, Green A, Santini S, Bizzarri AR, Cannistraro S, Gupta TK, Beattie CW. Yamada T, et al. Among authors: beattie cw. Br J Cancer. 2013 Jun 25;108(12):2495-504. doi: 10.1038/bjc.2013.266. Epub 2013 Jun 4. Br J Cancer. 2013. PMID: 23736031 Free PMC article.
224 results