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Reducing the peptidyl features of caspase-3 inhibitors: a structural analysis.
Becker JW, Rotonda J, Soisson SM, Aspiotis R, Bayly C, Francoeur S, Gallant M, Garcia-Calvo M, Giroux A, Grimm E, Han Y, McKay D, Nicholson DW, Peterson E, Renaud J, Roy S, Thornberry N, Zamboni R. Becker JW, et al. J Med Chem. 2004 May 6;47(10):2466-74. doi: 10.1021/jm0305523. J Med Chem. 2004. PMID: 15115390
Discovery of novel aspartyl ketone dipeptides as potent and selective caspase-3 inhibitors.
Han Y, Giroux A, Grimm EL, Aspiotis R, Francoeur S, Bayly CI, Mckay DJ, Roy S, Xanthoudakis S, Vaillancourt JP, Rasper DM, Tam J, Tawa P, Thornberry NA, Paterson EP, Garcia-Calvo M, Becker JW, Rotonda J, Nicholson DW, Zamboni RJ. Han Y, et al. Among authors: becker jw. Bioorg Med Chem Lett. 2004 Feb 9;14(3):805-8. doi: 10.1016/j.bmcl.2003.10.064. Bioorg Med Chem Lett. 2004. PMID: 14741294
The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis.
Rotonda J, Nicholson DW, Fazil KM, Gallant M, Gareau Y, Labelle M, Peterson EP, Rasper DM, Ruel R, Vaillancourt JP, Thornberry NA, Becker JW. Rotonda J, et al. Among authors: becker jw. Nat Struct Biol. 1996 Jul;3(7):619-25. doi: 10.1038/nsb0796-619. Nat Struct Biol. 1996. PMID: 8673606
The structural basis for the selectivity of benzotriazole inhibitors of PTP1B.
Scapin G, Patel SB, Becker JW, Wang Q, Desponts C, Waddleton D, Skorey K, Cromlish W, Bayly C, Therien M, Gauthier JY, Li CS, Lau CK, Ramachandran C, Kennedy BP, Asante-Appiah E. Scapin G, et al. Among authors: becker jw. Biochemistry. 2003 Oct 7;42(39):11451-9. doi: 10.1021/bi035098j. Biochemistry. 2003. PMID: 14516196
91 results