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Selective late sodium current inhibitor GS-458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia.
Bossu A, Houtman MJC, Meijborg VMF, Varkevisser R, Beekman HDM, Dunnink A, de Bakker JMT, Mollova N, Rajamani S, Belardinelli L, van der Heyden MAG, Vos MA. Bossu A, et al. Among authors: belardinelli l. Br J Pharmacol. 2018 Jun;175(12):2470-2482. doi: 10.1111/bph.14217. Epub 2018 May 6. Br J Pharmacol. 2018. PMID: 29582428 Free PMC article.
Robust anti-arrhythmic efficacy of verapamil and flunarizine against dofetilide-induced TdP arrhythmias is based upon a shared and a different mode of action.
Oros A, Houtman MJ, Neco P, Gomez AM, Rajamani S, Oosterhoff P, Attevelt NJ, Beekman JD, van der Heyden MA, Ver Donck L, Belardinelli L, Richard S, Antoons G, Vos MA; CONTICA investigators. Oros A, et al. Among authors: belardinelli l. Br J Pharmacol. 2010 Sep;161(1):162-75. doi: 10.1111/j.1476-5381.2010.00883.x. Br J Pharmacol. 2010. PMID: 20718748 Free PMC article.
Ranolazine improves diastolic dysfunction in isolated myocardium from failing human hearts--role of late sodium current and intracellular ion accumulation.
Sossalla S, Wagner S, Rasenack EC, Ruff H, Weber SL, Schöndube FA, Tirilomis T, Tenderich G, Hasenfuss G, Belardinelli L, Maier LS. Sossalla S, et al. Among authors: belardinelli l. J Mol Cell Cardiol. 2008 Jul;45(1):32-43. doi: 10.1016/j.yjmcc.2008.03.006. Epub 2008 Mar 14. J Mol Cell Cardiol. 2008. PMID: 18439620
Rapid kinetic interactions of ranolazine with HERG K+ current.
Rajamani S, Shryock JC, Belardinelli L. Rajamani S, et al. Among authors: belardinelli l. J Cardiovasc Pharmacol. 2008 Jun;51(6):581-9. doi: 10.1097/FJC.0b013e3181799690. J Cardiovasc Pharmacol. 2008. PMID: 18520952
Ranolazine as an adjunct to cardioplegia: a potential new therapeutic application.
Hwang H, Arcidi JM Jr, Hale SL, Simkhovich BZ, Belardinelli L, Dhalla AK, Shryock JC, Kloner RA. Hwang H, et al. Among authors: belardinelli l. J Cardiovasc Pharmacol Ther. 2009 Jun;14(2):125-33. doi: 10.1177/1074248409333491. Epub 2009 Mar 27. J Cardiovasc Pharmacol Ther. 2009. PMID: 19329672
386 results