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Dihydroxythiophenes are novel potent inhibitors of human immunodeficiency virus integrase with a diketo acid-like pharmacophore.
Kehlenbeck S, Betz U, Birkmann A, Fast B, Göller AH, Henninger K, Lowinger T, Marrero D, Paessens A, Paulsen D, Pevzner V, Schohe-Loop R, Tsujishita H, Welker R, Kreuter J, Rübsamen-Waigmann H, Dittmer F. Kehlenbeck S, et al. Among authors: birkmann a. J Virol. 2006 Jul;80(14):6883-94. doi: 10.1128/JVI.00306-06. J Virol. 2006. PMID: 16809294 Free PMC article.
Pharmacokinetics-pharmacodynamics of the helicase-primase inhibitor pritelivir following treatment of wild-type or pritelivir-resistant virus infection in a murine herpes simplex virus 1 infection model.
Biswas S, Sukla S, Goldner T, Field HJ, Kropeit D, Paulsen D, Welbers A, Ruebsamen-Schaeff H, Zimmermann H, Birkmann A. Biswas S, et al. Among authors: birkmann a. Antimicrob Agents Chemother. 2014 Jul;58(7):3843-52. doi: 10.1128/AAC.02641-14. Epub 2014 Apr 21. Antimicrob Agents Chemother. 2014. PMID: 24752278 Free PMC article.
Mismatch primer-based PCR reveals that helicase-primase inhibitor resistance mutations pre-exist in herpes simplex virus type 1 clinical isolates and are not induced during incubation with the inhibitor.
Sukla S, Biswas S, Birkmann A, Lischka P, Zimmermann H, Field HJ. Sukla S, et al. Among authors: birkmann a. J Antimicrob Chemother. 2010 Jul;65(7):1347-52. doi: 10.1093/jac/dkq135. Epub 2010 May 7. J Antimicrob Chemother. 2010. PMID: 20453068 Free PMC article.
Helicase-primase inhibitor pritelivir for HSV-2 infection.
Wald A, Corey L, Timmler B, Magaret A, Warren T, Tyring S, Johnston C, Kriesel J, Fife K, Galitz L, Stoelben S, Huang ML, Selke S, Stobernack HP, Ruebsamen-Schaeff H, Birkmann A. Wald A, et al. Among authors: birkmann a. N Engl J Med. 2014 Jan 16;370(3):201-10. doi: 10.1056/NEJMoa1301150. N Engl J Med. 2014. PMID: 24428466 Free article. Clinical Trial.
No Evidence of Pritelivir Resistance Among Herpes Simplex Virus Type 2 Isolates After 4 Weeks of Daily Therapy.
Edlefsen PT, Birkmann A, Huang ML, Magaret CA, Kee JJ, Diem K, Goldner T, Timmler B, Stoelben S, Ruebsamen-Schaeff H, Zimmermann H, Warren T, Wald A, Corey L. Edlefsen PT, et al. Among authors: birkmann a. J Infect Dis. 2016 Jul 15;214(2):258-64. doi: 10.1093/infdis/jiw129. Epub 2016 Apr 7. J Infect Dis. 2016. PMID: 27056950 Free PMC article. Clinical Trial.
30 results