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Treatment of gastric carcinoids type 1 with the gastrin receptor antagonist netazepide (YF476) results in regression of tumours and normalisation of serum chromogranin A.
Fossmark R, Sørdal Ø, Jianu CS, Qvigstad G, Nordrum IS, Boyce M, Waldum HL. Fossmark R, et al. Among authors: boyce m. Aliment Pharmacol Ther. 2012 Dec;36(11-12):1067-75. doi: 10.1111/apt.12090. Epub 2012 Oct 16. Aliment Pharmacol Ther. 2012. PMID: 23072686 Free article. Clinical Trial.
Netazepide, a gastrin receptor antagonist, normalises tumour biomarkers and causes regression of type 1 gastric neuroendocrine tumours in a nonrandomised trial of patients with chronic atrophic gastritis.
Moore AR, Boyce M, Steele IA, Campbell F, Varro A, Pritchard DM. Moore AR, et al. Among authors: boyce m. PLoS One. 2013 Oct 1;8(10):e76462. doi: 10.1371/journal.pone.0076462. eCollection 2013. PLoS One. 2013. PMID: 24098507 Free PMC article. Clinical Trial.
Skeletal effects of a gastrin receptor antagonist in H+/K+ATPase beta subunit KO mice.
Aasarød KM, Ramezanzadehkoldeh M, Shabestari M, Mosti MP, Stunes AK, Reseland JE, Beisvag V, Eriksen EF, Sandvik AK, Erben RG, Schüler C, Boyce M, Skallerud BH, Syversen U, Fossmark R. Aasarød KM, et al. Among authors: boyce m. J Endocrinol. 2016 Aug;230(2):251-62. doi: 10.1530/JOE-16-0017. Epub 2016 Jun 20. J Endocrinol. 2016. PMID: 27325243
The type 2 CCK/gastrin receptor antagonist YF476 acutely prevents NSAID-induced gastric ulceration while increasing iNOS expression.
Webb DL, Rudholm-Feldreich T, Gillberg L, Halim MA, Theodorsson E, Sanger GJ, Campbell CA, Boyce M, Näslund E, Hellström PM. Webb DL, et al. Among authors: boyce m. Naunyn Schmiedebergs Arch Pharmacol. 2013 Jan;386(1):41-9. doi: 10.1007/s00210-012-0812-5. Epub 2012 Nov 24. Naunyn Schmiedebergs Arch Pharmacol. 2013. PMID: 23179899
482 results