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Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants.
Pilling LC, Atkins JL, Bowman K, Jones SE, Tyrrell J, Beaumont RN, Ruth KS, Tuke MA, Yaghootkar H, Wood AR, Freathy RM, Murray A, Weedon MN, Xue L, Lunetta K, Murabito JM, Harries LW, Robine JM, Brayne C, Kuchel GA, Ferrucci L, Frayling TM, Melzer D. Pilling LC, et al. Among authors: brayne c. Aging (Albany NY). 2016 Mar;8(3):547-60. doi: 10.18632/aging.100930. Aging (Albany NY). 2016. PMID: 27015805 Free PMC article.
Genetic variants influencing human aging from late-onset Alzheimer's disease (LOAD) genome-wide association studies (GWAS).
Shi H, Belbin O, Medway C, Brown K, Kalsheker N, Carrasquillo M, Proitsi P, Powell J, Lovestone S, Goate A, Younkin S, Passmore P; Genetic and Environmental Risk for Alzheimer's Disease Consortium; Morgan K; Alzheimer's Research UK Consortium. Shi H, et al. Neurobiol Aging. 2012 Aug;33(8):1849.e5-18. doi: 10.1016/j.neurobiolaging.2012.02.014. Epub 2012 Mar 23. Neurobiol Aging. 2012. PMID: 22445811 Free PMC article.
Alleles that increase risk for type 2 diabetes mellitus are not associated with increased risk for Alzheimer's disease.
Proitsi P, Lupton MK, Velayudhan L, Hunter G, Newhouse S, Lin K, Fogh I, Tsolaki M, Daniilidou M, Pritchard M, Craig D, Todd S, Johnston JA, McGuinness B, Kloszewska I, Soininen H, Mecocci P, Vellas B, Passmore PA, Sims R, Williams J, Brayne C; Alzheimer's Disease Neuroimaging Initiative; GERAD1 Consortium; Stewart R, Sham P, Lovestone S, Powell JF. Proitsi P, et al. Among authors: brayne c. Neurobiol Aging. 2014 Dec;35(12):2883.e3-2883.e10. doi: 10.1016/j.neurobiolaging.2014.07.023. Epub 2014 Jul 24. Neurobiol Aging. 2014. PMID: 25150574
Obesity in Older People With and Without Conditions Associated With Weight Loss: Follow-up of 955,000 Primary Care Patients.
Bowman K, Delgado J, Henley WE, Masoli JA, Kos K, Brayne C, Thokala P, Lafortune L, Kuchel GA, Ble A, Melzer D; as part of the Ageing Well Programme of the NIHR School for Public Health Research, England. Bowman K, et al. Among authors: brayne c. J Gerontol A Biol Sci Med Sci. 2017 Feb;72(2):203-209. doi: 10.1093/gerona/glw147. Epub 2016 Aug 4. J Gerontol A Biol Sci Med Sci. 2017. PMID: 27492450 Free PMC article.
Outcomes of Treated Hypertension at Age 80 and Older: Cohort Analysis of 79,376 Individuals.
Delgado J, Masoli JAH, Bowman K, Strain WD, Kuchel GA, Walters K, Lafortune L, Brayne C, Melzer D, Ble A; As part of the Ageing Well Programme of the NIHR School for Public Health Research, England. Delgado J, et al. Among authors: brayne c. J Am Geriatr Soc. 2017 May;65(5):995-1003. doi: 10.1111/jgs.14712. Epub 2016 Dec 30. J Am Geriatr Soc. 2017. PMID: 28039870 Free PMC article.
841 results