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Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fibre branching.
Ahn B, Ranjit R, Premkumar P, Pharaoh G, Piekarz KM, Matsuzaki S, Claflin DR, Riddle K, Judge J, Bhaskaran S, Satara Natarajan K, Barboza E, Wronowski B, Kinter M, Humphries KM, Griffin TM, Freeman WM, Richardson A, Brooks SV, Van Remmen H. Ahn B, et al. Among authors: brooks sv. J Cachexia Sarcopenia Muscle. 2019 Apr;10(2):411-428. doi: 10.1002/jcsm.12375. Epub 2019 Feb 1. J Cachexia Sarcopenia Muscle. 2019. PMID: 30706998 Free PMC article.
mTORC1 underlies age-related muscle fiber damage and loss by inducing oxidative stress and catabolism.
Tang H, Inoki K, Brooks SV, Okazawa H, Lee M, Wang J, Kim M, Kennedy CL, Macpherson PCD, Ji X, Van Roekel S, Fraga DA, Wang K, Zhu J, Wang Y, Sharp ZD, Miller RA, Rando TA, Goldman D, Guan KL, Shrager JB. Tang H, et al. Among authors: brooks sv. Aging Cell. 2019 Jun;18(3):e12943. doi: 10.1111/acel.12943. Epub 2019 Mar 29. Aging Cell. 2019. PMID: 30924297 Free PMC article.
121 results