Brown ML - Search Results

1

Bicyclic hydantoins with a bridgehead nitrogen. Comparison of anticonvulsant activities with binding to the neuronal voltage-dependent sodium channel.

Brouillette WJ, Jestkov VP, Brown ML, Akhtar MS, DeLorey TM, Brown GB. Brouillette WJ, et al. Among authors: brown gb, brown ml. J Med Chem. 1994 Sep 30;37(20):3289-93. doi: 10.1021/jm00046a013. J Med Chem. 1994. PMID: 7932556

2

Effects of log P and phenyl ring conformation on the binding of 5-phenylhydantoins to the voltage-dependent sodium channel.

Brown ML, Brown GB, Brouillette WJ. Brown ML, et al. Among authors: brown gb. J Med Chem. 1997 Feb 14;40(4):602-7. doi: 10.1021/jm960692v. J Med Chem. 1997. PMID: 9046351

3

Comparative molecular field analysis of hydantoin binding to the neuronal voltage-dependent sodium channel.

Brown ML, Zha CC, Van Dyke CC, Brown GB, Brouillette WJ. Brown ML, et al. Among authors: brown gb. J Med Chem. 1999 May 6;42(9):1537-45. doi: 10.1021/jm980556l. J Med Chem. 1999. PMID: 10229624

4

Ligand-based design and synthesis of novel sodium channel blockers from a combined phenytoin-lidocaine pharmacophore.

Wang Y, Jones PJ, Batts TW, Landry V, Patel MK, Brown ML. Wang Y, et al. Among authors: brown ml. Bioorg Med Chem. 2009 Oct 1;17(19):7064-72. doi: 10.1016/j.bmc.2008.10.031. Epub 2008 Oct 17. Bioorg Med Chem. 2009. PMID: 19346132 Free PMC article.

5

Design, synthesis, and evaluation of analogues of 3,3,3-trifluoro-2-hydroxy-2-phenyl-propionamide as orally available general anesthetics.

Choudhury-Mukherjee I, Schenck HA, Cechova S, Pajewski TN, Kapur J, Ellena J, Cafiso DS, Brown ML. Choudhury-Mukherjee I, et al. Among authors: brown ml. J Med Chem. 2003 Jun 5;46(12):2494-501. doi: 10.1021/jm020546r. J Med Chem. 2003. PMID: 12773053

6

Design, synthesis and evaluation of novel hydroxyamides as orally available anticonvulsants.

Schenck HA, Lenkowski PW, Choudhury-Mukherjee I, Ko SH, Stables JP, Patel MK, Brown ML. Schenck HA, et al. Among authors: brown ml. Bioorg Med Chem. 2004 Mar 1;12(5):979-93. doi: 10.1016/j.bmc.2003.12.011. Bioorg Med Chem. 2004. PMID: 14980611

7

Asymmetric synthesis and evaluation of a hydroxyphenylamide voltage-gated sodium channel blocker in human prostate cancer xenografts.

Davis GC, Kong Y, Paige M, Li Z, Merrick EC, Hansen T, Suy S, Wang K, Dakshanamurthy S, Cordova A, McManus OB, Williams BS, Chruszcz M, Minor W, Patel MK, Brown ML. Davis GC, et al. Among authors: brown ml. Bioorg Med Chem. 2012 Mar 15;20(6):2180-8. doi: 10.1016/j.bmc.2011.08.061. Epub 2011 Sep 1. Bioorg Med Chem. 2012. PMID: 22364743 Free PMC article.

8

Synthesis and evaluation of substituted 4-aryloxy- and 4-arylsulfanyl-phenyl-2-aminothiazoles as inhibitors of human breast cancer cell proliferation.

Gorczynski MJ, Leal RM, Mooberry SL, Bushweller JH, Brown ML. Gorczynski MJ, et al. Among authors: brown ml. Bioorg Med Chem. 2004 Mar 1;12(5):1029-36. doi: 10.1016/j.bmc.2003.12.003. Bioorg Med Chem. 2004. PMID: 14980616

9

Comparative molecular field analysis and synthetic validation of a hydroxyamide-propofol binding and functional block of neuronal voltage-dependent sodium channels.

Brown ML, Eidam HA, Paige M, Jones PJ, Patel MK. Brown ML, et al. Bioorg Med Chem. 2009 Oct 1;17(19):7056-63. doi: 10.1016/j.bmc.2008.11.069. Epub 2008 Dec 3. Bioorg Med Chem. 2009. PMID: 19747831 Free PMC article.

10

Design, synthesis, and development of novel caprolactam anticonvulsants.

Grimm JB, Stables JP, Brown ML. Grimm JB, et al. Among authors: brown ml. Bioorg Med Chem. 2003 Sep 1;11(18):4133-41. doi: 10.1016/s0968-0896(03)00400-0. Bioorg Med Chem. 2003. PMID: 12927875

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