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A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins.
Lu X, Chandravanshi M, Sabbasani VR, Gaikwad S, Hughitt VK, Gyabaah-Kessie N, Scroggins BT, Das S, Myint W, Clapp ME, Schwieters CD, Dyba MA, Bolhuis DL, Koscielniak JW, Andresson T, Emanuele MJ, Brown NG, Matsuo H, Chari R, Citrin DE, Mock BA, Swenson RE, Walters KJ. Lu X, et al. Among authors: brown ng. Nat Commun. 2024 Mar 20;15(1):2485. doi: 10.1038/s41467-024-46644-7. Nat Commun. 2024. PMID: 38509117 Free PMC article.
Multi-monoubiquitylation controls VASP-mediated actin dynamics.
McCormick LE, Suarez C, Herring LE, Cannon KS, Kovar DR, Brown NG, Gupton SL. McCormick LE, et al. Among authors: brown ng. J Cell Sci. 2024 Jan 15;137(2):jcs261527. doi: 10.1242/jcs.261527. Epub 2024 Jan 26. J Cell Sci. 2024. PMID: 38277158 Free PMC article.
Recruitment of FBXO22 for Targeted Degradation of NSD2.
Nie DY, Tabor JR, Li J, Kutera M, St-Germain J, Hanley RP, Wolf E, Paulakonis E, Kenney TMG, Duan S, Shrestha S, Owens DDG, Pon A, Szewczyk M, Lamberto AJ, Menes M, Li F, Barsyte-Lovejoy D, Brown NG, Barsotti AM, Stamford AW, Collins JL, Wilson DJ, Raught B, Licht JD, James LI, Arrowsmith CH. Nie DY, et al. Among authors: brown ng. bioRxiv [Preprint]. 2023 Nov 30:2023.11.01.564830. doi: 10.1101/2023.11.01.564830. bioRxiv. 2023. PMID: 37961297 Free PMC article. Preprint.
Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C).
Bodrug T, Welsh KA, Bolhuis DL, Paulаkonis E, Martinez-Chacin RC, Liu B, Pinkin N, Bonacci T, Cui L, Xu P, Roscow O, Amann SJ, Grishkovskaya I, Emanuele MJ, Harrison JS, Steimel JP, Hahn KM, Zhang W, Zhong ED, Haselbach D, Brown NG. Bodrug T, et al. Among authors: brown ng. Nat Struct Mol Biol. 2023 Nov;30(11):1663-1674. doi: 10.1038/s41594-023-01105-5. Epub 2023 Sep 21. Nat Struct Mol Biol. 2023. PMID: 37735619 Free PMC article.
Multi-monoubiquitination controls VASP-mediated actin dynamics.
McCormick LE, Suarez C, Herring LE, Cannon KS, Kovar DR, Brown NG, Gupton SL. McCormick LE, et al. Among authors: brown ng. bioRxiv [Preprint]. 2023 Jul 17:2023.07.16.549237. doi: 10.1101/2023.07.16.549237. bioRxiv. 2023. PMID: 37503134 Free PMC article. Preprint.
Cryo-EM structure of the chain-elongating E3 ubiquitin ligase UBR5.
Hodáková Z, Grishkovskaya I, Brunner HL, Bolhuis DL, Belačić K, Schleiffer A, Kotisch H, Brown NG, Haselbach D. Hodáková Z, et al. Among authors: brown ng. EMBO J. 2023 Aug 15;42(16):e113348. doi: 10.15252/embj.2022113348. Epub 2023 Jul 6. EMBO J. 2023. PMID: 37409633 Free PMC article.
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