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Regulation of the transcriptional coactivator FHL2 licenses activation of the androgen receptor in castrate-resistant prostate cancer.
McGrath MJ, Binge LC, Sriratana A, Wang H, Robinson PA, Pook D, Fedele CG, Brown S, Dyson JM, Cottle DL, Cowling BS, Niranjan B, Risbridger GP, Mitchell CA. McGrath MJ, et al. Among authors: brown s. Cancer Res. 2013 Aug 15;73(16):5066-79. doi: 10.1158/0008-5472.CAN-12-4520. Epub 2013 Jun 25. Cancer Res. 2013. PMID: 23801747
FHL3 is an actin-binding protein that regulates alpha-actinin-mediated actin bundling: FHL3 localizes to actin stress fibers and enhances cell spreading and stress fiber disassembly.
Coghill ID, Brown S, Cottle DL, McGrath MJ, Robinson PA, Nandurkar HH, Dyson JM, Mitchell CA. Coghill ID, et al. Among authors: brown s. J Biol Chem. 2003 Jun 27;278(26):24139-52. doi: 10.1074/jbc.M213259200. Epub 2003 Apr 18. J Biol Chem. 2003. PMID: 12704194 Free article.
FHL3 binds MyoD and negatively regulates myotube formation.
Cottle DL, McGrath MJ, Cowling BS, Coghill ID, Brown S, Mitchell CA. Cottle DL, et al. Among authors: brown s. J Cell Sci. 2007 Apr 15;120(Pt 8):1423-35. doi: 10.1242/jcs.004739. Epub 2007 Mar 27. J Cell Sci. 2007. PMID: 17389685
Characterization of two isoforms of the skeletal muscle LIM protein 1, SLIM1. Localization of SLIM1 at focal adhesions and the isoform slimmer in the nucleus of myoblasts and cytoplasm of myotubes suggests distinct roles in the cytoskeleton and in nuclear-cytoplasmic communication.
Brown S, McGrath MJ, Ooms LM, Gurung R, Maimone MM, Mitchell CA. Brown S, et al. J Biol Chem. 1999 Sep 17;274(38):27083-91. doi: 10.1074/jbc.274.38.27083. J Biol Chem. 1999. PMID: 10480922 Free article.
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