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In vitro crosstalk between fibroblasts and native human acute myelogenous leukemia (AML) blasts via local cytokine networks results in increased proliferation and decreased apoptosis of AML cells as well as increased levels of proangiogenic Interleukin 8.
Ryningen A, Wergeland L, Glenjen N, Gjertsen BT, Bruserud O. Ryningen A, et al. Among authors: bruserud o. Leuk Res. 2005 Feb;29(2):185-96. doi: 10.1016/j.leukres.2004.06.008. Leuk Res. 2005. PMID: 15607368
Release of angiopoietin-1 by primary human acute myelogenous leukemia cells is associated with mutations of nucleophosmin, increased by bone marrow stromal cells and possibly antagonized by high systemic angiopoietin-2 levels.
Hatfield KJ, Hovland R, Øyan AM, Kalland KH, Ryningen A, Gjertsen BT, Bruserud Ø. Hatfield KJ, et al. Among authors: bruserud o. Leukemia. 2008 Feb;22(2):287-93. doi: 10.1038/sj.leu.2404985. Epub 2007 Oct 18. Leukemia. 2008. PMID: 17943167
442 results