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Monocarboxylate transporter MCT1 is a target for immunosuppression.
Murray CM, Hutchinson R, Bantick JR, Belfield GP, Benjamin AD, Brazma D, Bundick RV, Cook ID, Craggs RI, Edwards S, Evans LR, Harrison R, Holness E, Jackson AP, Jackson CG, Kingston LP, Perry MW, Ross AR, Rugman PA, Sidhu SS, Sullivan M, Taylor-Fishwick DA, Walker PC, Whitehead YM, Wilkinson DJ, Wright A, Donald DK. Murray CM, et al. Among authors: bundick rv. Nat Chem Biol. 2005 Dec;1(7):371-6. doi: 10.1038/nchembio744. Nat Chem Biol. 2005. PMID: 16370372
The specific monocarboxylate transporter-1 (MCT-1) inhibitor, AR-C117977, induces donor-specific suppression, reducing acute and chronic allograft rejection in the rat.
Ekberg H, Qi Z, Pahlman C, Veress B, Bundick RV, Craggs RI, Holness E, Edwards S, Murray CM, Ferguson D, Kerry PJ, Wilson E, Donald DK. Ekberg H, et al. Among authors: bundick rv. Transplantation. 2007 Nov 15;84(9):1191-9. doi: 10.1097/01.tp.0000287541.53389.be. Transplantation. 2007. PMID: 17998876
Immunology: turning basic research into a therapy.
Leishman AJ, Bundick RV. Leishman AJ, et al. Among authors: bundick rv. Immunol Lett. 2005 Jun 15;99(1):1-7. doi: 10.1016/j.imlet.2004.12.011. Epub 2005 Jan 12. Immunol Lett. 2005. PMID: 15894103 Review.
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